Evidence map›Paper›PMID 34495694›Full record

ArticleJournal of virology2021

Two Interferon-Stimulated Response Elements Cooperatively Regulate Interferon-Stimulated Gene Expression in West Nile Virus-Infected IFNAR

Dan Cui, Emilio E Espínola, Komal Arora, Margo A Brinton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dan CuiGeorgia State Universitygrid.256304.6, Atlanta, Georgia, USA.
Emilio E EspínolaGeorgia State Universitygrid.256304.6, Atlanta, Georgia, USA.
Komal AroraGeorgia State Universitygrid.256304.6, Atlanta, Georgia, USA.
Margo A BrintonGeorgia State Universitygrid.256304.6, Atlanta, Georgia, USA.ORCID 0000-0003-4868-175X
Georgia State University · US

Funding

Alternative regulation of ISGs in WNV-infected cellsR21AI097851 · NIAID · GEORGIA STATE UNIVERSITY · PI BRINTON, MARGO A · 2012 to 2013
$395k
Consejo Nacional de Ciencia y Tecnología, Paraguay (CONACYT) PRONII FellowshipGeorgia State University (GSU) Molecular Basis of Disease FellowshipHHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21AI097851NIAID NIH HHS R21 AI097851
6 · The paper itself

Abstract

We previously identified a subset of interferon-stimulated genes (ISGs) upregulated by West Nile virus (WNV) infection in wild-type mouse embryo fibroblasts (MEFs) after viral proteins had inhibited type I interferon (IFN)-mediated JAK-STAT signaling and also in WNV-infected RIG-I

Indexed as

FibroblastsAnimalsGene Expression RegulationInterferon Type IMiceMice, Inbred C57BLMice, KnockoutResponse ElementsWest Nile FeverWest Nile virusInterferon Type IIFNAR−/− MEFsIRF3IRF5IRF7ISGISRENF-κBtype I IFNWest Nile virusWNV

Identifiers

PMID34495694
PMCPMC8549515
OpenAlexW3198422958

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.