Evidence map›Paper›PMID 34495675›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Soluble (Pro)Renin Receptor as a Negative Regulator of NCC (Na

Chuanming Xu, Yanting Chen, Fei Wang, Shiying Xie, Tianxin Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Chuanming XuFrom the Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City (C.X., Y.C., F.W.,T.X.).ORCID 0000-0001-7082-2833
Yanting ChenFrom the Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City (C.X., Y.C., F.W.,T.X.).
Fei WangFrom the Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City (C.X., Y.C., F.W.,T.X.).ORCID 0000-0001-8405-3561
Shiying XieInstitute of Hypertension, Sun Yat-sen University School of Medicine, Guangzhou, China (S.X.).
Tianxin YangFrom the Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City (C.X., Y.C., F.W.,T.X.).ORCID 0000-0003-4209-2284

Funding

Interaction of PGE2 and intrarenal RAS in AngII-induced hypertensionR01DK104072 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI YANG, TIANXIN · 2015 to 2025
$3.7M
Role of (pro)renin receptor in aldosterone signaling in the kidneyR01HL139689 · NHLBI · UNIVERSITY OF UTAH · PI YANG, TIANXIN · 2018 to 2021
$2.3M
Interaction of (pro)renin receptor and PPARy in regulation of plasma volumeR01HL135851 · NHLBI · UNIVERSITY OF UTAH · PI YANG, TIANXIN · 2017 to 2021
$2.3M
Role of CTRP1 in Renal Sodium Handling in Obesity-Related HypertensionK99HL155850 · NHLBI · UNIVERSITY OF UTAH · PI WANG, FEI · 2021 to 2022
$180k
BLRD VA I01 BX004871BLRD VA IK6 BX005223NHLBI NIH HHS K99 HL155850NHLBI NIH HHS R01 HL135851NHLBI NIH HHS R01 HL139689NIDDK NIH HHS R01 DK104072
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AnimalsHyperkalemiaKidney Tubules, DistalMicePhosphorylationProrenin ReceptorProtein Serine-Threonine KinasesPyrrolidinesReceptors, Cell SurfaceSolute Carrier Family 12, Member 3OXSR1 protein, mousePF-429242Prkwnk4 protein, mouseProrenin ReceptorProtein Serine-Threonine KinasesPyrrolidinesReceptors, Cell SurfaceSolute Carrier Family 12, Member 3Stk39 protein, mouseangiotensin II receptor type 1arterial pressurehyperkalemiaNa+-K+ cotransportersoluble (pro)renin receptor

Identifiers

PMID34495675
PMCPMC9212213

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.