Evidence map›Paper›PMID 34495648›Full record

ArticleBiochemistry2021

Beyond the Plateau: pL Dependence of Proton Inventories as a Tool for Studying Ribozyme and Ribonuclease Catalysis.

Suhyun Yoon, Michael E Harris

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Suhyun YoonDepartment of Chemistry, University of Florida, Gainesville, Florida 32611-7200, United States.ORCID 0000-0002-3764-0381
Michael E HarrisDepartment of Chemistry, University of Florida, Gainesville, Florida 32611-7200, United States.ORCID 0000-0001-8977-4392
University of Florida · US

Funding

Specificity in Substrate Recognition and Catalysis by RNA Processing EnzymesR35GM127100 · NIGMS · UNIVERSITY OF FLORIDA · PI HARRIS, MICHAEL E. · 2018 to 2022
$1.6M
NIGMS NIH HHS R35 GM127100
6 · The paper itself

Abstract

Acid/base catalysis is an important catalytic strategy used by ribonucleases and ribozymes; however, understanding the number and identity of functional groups involved in proton transfer remains challenging. The proton inventory (PI) technique analyzes the dependence of the enzyme reaction rate on the ratio of D

Indexed as

Acid-Base EquilibriumCatalysisCatalytic DomainHepatitis Delta VirusHydrogen-Ion ConcentrationKineticsNucleic Acid ConformationProtonsRibonucleasesRNA, CatalyticSolventsProtonsRibonucleasesRNA, CatalyticSolvents

Identifiers

PMID34495648
PMCPMC9206726
OpenAlexW3196968916

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.