Evidence map›Paper›PMID 34495570›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Pathogenic T Cells in Celiac Disease Change Phenotype on Gluten Challenge: Implications for T-Cell-Directed Therapies.

Asbjørn Christophersen, Stephanie Zühlke, Eivind G Lund, Omri Snir, Shiva Dahal-Koirala, Louise Fremgaard Risnes, Jørgen Jahnsen, Knut E A Lundin, Ludvig M Sollid

Erratum issued Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02464150 (Gluten Challenge in Celiac Disease), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02464150 nacompletednot on this map

Gluten Challenge in Celiac Disease

TypeinterventionalSponsorOslo University HospitalRan2017 to 2025Enrolled99ConditionsCeliac DiseaseArmsGluten challenge
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Gliadin-specific CD4Science advances · 2026
    Article
  3. T cell receptors for antigen on intraepithelial cytolytic T lymphocytes in celiac disease engage enterocyte HLA-E and HLA-B.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Phenotype-Based Isolation of Antigen-Specific CD4Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Asbjørn ChristophersenKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, 0372, Norway.ORCID 0000-0003-4049-807X
Stephanie ZühlkeKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, 0372, Norway.ORCID 0000-0003-1012-7526
Eivind G LundKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, 0372, Norway.
Omri SnirKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, 0372, Norway.
Shiva Dahal-KoiralaKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, 0372, Norway.
Louise Fremgaard RisnesKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, 0372, Norway.
Jørgen JahnsenInstitute of Clinical Medicine, University of Oslo, Oslo, 0450, Norway.
Knut E A LundinKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, 0372, Norway.
Ludvig M SollidKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, 0372, Norway.
University of Oslo · NOOslo University Hospital · NO

Funding

Helse Sør-Øst RHF 2016113Helse Sør-Øst RHF 2018068Stiftelsen KG Jebsen SKGJ-MED-017University of Oslo World-Leading Research Program on Human Immunology WL-IMMUNOLOGY
6 · The paper itself

Abstract

Gluten-specific CD4

Indexed as

ADP-ribosyl Cyclase 1Antigens, CDCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCeliac DiseaseGlutensHLA-DQ AntigensHumansImmunotherapyIntegrin alpha ChainsIntraepithelial LymphocytesPhenotypeProtein MultimerizationADP-ribosyl Cyclase 1alpha E integrinsAntigens, CDGlutensHLA-DQ2 antigenHLA-DQ AntigensIntegrin alpha Chainsceliac diseasegluten challengemass cytometryRNA-SeqT cells

Identifiers

PMID34495570
PMCPMC8564461
OpenAlexW3197553502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.