Evidence map›Paper›PMID 34495544›Full record

ArticleAdvances in experimental medicine and biology2021

Glycosylation and Aging.

Ana Cindrić, Jasminka Krištić, Marina Martinić Kavur, Marija Pezer

Abstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. TrimmedTheranostics · 2025
    Article
  7. Protein N -Glycans in Healthy and Sclerotic Glomeruli in Diabetic Kidney Disease.Journal of the American Society of Nephrology : JASN · 2024
    Article
  8. Glycosylation in aging and neurodegenerative diseases.Acta biochimica et biophysica Sinica · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Age-Related Changes in SerumBiomolecules · 2023
    Article
  14. Review
  15. High-Throughput Glycomic Methods.Chemical reviews · 2022
    Review
  16. The dynamic brain N-glycome.Glycoconjugate journal · 2022
    Review
  17. Molecules (Basel, Switzerland) · 2022
    Article
  18. Spatial Mapping of PlantFrontiers in plant science · 2022
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Ana CindrićGenos Glycoscience Research Laboratory, Zagreb, Croatia.
Jasminka KrištićGenos Glycoscience Research Laboratory, Zagreb, Croatia.
Marina Martinić KavurGenos Glycoscience Research Laboratory, Zagreb, Croatia.
Marija PezerGenos Glycoscience Research Laboratory, Zagreb, Croatia. mpezer@genos.hr.
Genos (Croatia) · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human lifespan has increased significantly in the last 200 years, emphasizing our need to age healthily. Insights into molecular mechanisms of aging might allow us to slow down its rate or even revert it. Similar to aging, glycosylation is regulated by an intricate interplay of genetic and environmental factors. The dynamics of glycopattern variation during aging has been mostly explored for plasma/serum and immunoglobulin G (IgG) N-glycome, as we describe thoroughly in this chapter. In addition, we discuss the potential functional role of agalactosylated IgG glycans in aging, through modulation of inflammation level, as proposed by the concept of inflammaging. We also comment on the potential to use the plasma/serum and IgG N-glycome as a biomarker of healthy aging and on the interventions that modulate the IgG glycopattern. Finally, we discuss the current knowledge about animal models for human plasma/serum and IgG glycosylation and mention other, less explored, instances of glycopattern changes during organismal aging and cellular senescence.

Indexed as

AgingPolysaccharidesAnimalsGlycosylationHumansImmunoglobulin GLongevityImmunoglobulin GPolysaccharidesAgingBiological ageGlycosylationIgG N-glycomeInflammagingPlasma N-glycome

Identifiers

PMID34495544
OpenAlexW3197817059

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.