Evidence map›Paper›PMID 34495434›Full record

ArticleThe ultrasound journal2021

First diagnosis of multisystem inflammatory syndrome in children (MIS-C): an analysis of PoCUS findings in the ED.

Angelo G Delmonaco, Andrea Carpino, Irene Raffaldi, Giulia Pruccoli, Emanuela Garrone, Francesco Del Monte, Lorenzo Riboldi, Francesco Licciardi, Antonio F Urbino, Emilia Parodi

Open access · goldAbstract read
In one paragraph

Article in The ultrasound journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Angelo G DelmonacoDepartment of Pediatric Emergency, Regina Margherita Children's Hospital, A.O.U. Città Della Salute E Della Scienza Di Torino, Turin, Italy.
Andrea CarpinoPostgraduate School of Pediatrics, University of Turin, Piazza Polonia 94, 10126, Turin, Italy. andrea.carpino@unito.it.ORCID http://orcid.org/0000-0003-2040-9228
Irene RaffaldiDepartment of Pediatric Emergency, Regina Margherita Children's Hospital, A.O.U. Città Della Salute E Della Scienza Di Torino, Turin, Italy.
Giulia PruccoliDepartment of Pediatric and Public Health Sciences, Regina Margherita Children's Hospital, A.O.U. Città Della Salute E Della Scienza Di Torino, University of Turin, Turin, Italy.
Emanuela GarroneDepartment of Pediatric Emergency, Regina Margherita Children's Hospital, A.O.U. Città Della Salute E Della Scienza Di Torino, Turin, Italy.
Francesco Del MontePostgraduate School of Pediatrics, University of Turin, Piazza Polonia 94, 10126, Turin, Italy.
Lorenzo RiboldiPostgraduate School of Pediatrics, University of Turin, Piazza Polonia 94, 10126, Turin, Italy.
Francesco LicciardiDepartment of Pediatric and Public Health Sciences, Regina Margherita Children's Hospital, A.O.U. Città Della Salute E Della Scienza Di Torino, University of Turin, Turin, Italy.
Antonio F UrbinoDepartment of Pediatric Emergency, Regina Margherita Children's Hospital, A.O.U. Città Della Salute E Della Scienza Di Torino, Turin, Italy.
Emilia ParodiDepartment of Pediatric and Public Health Sciences, Regina Margherita Children's Hospital, A.O.U. Città Della Salute E Della Scienza Di Torino, University of Turin, Turin, Italy.
Ospedale Regina Margherita · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children with multisystem inflammatory syndrome (MIS-C) tend to develop a clinical condition of fluid overload due both to contractile cardiac pump deficit and to endotheliitis with subsequent capillary leak syndrome. In this context, the ability of point-of-care ultrasound (PoCUS) to simultaneously explore multiple systems and detect polyserositis could promote adequate therapeutic management of fluid balance. We describe the PoCUS findings in a case-series of MIS-C patients admitted to the Emergency Department. At admission 10/11 patients showed satisfactory clinical condition without signs and symptoms suggestive for cardiovascular impairment/shock, but PoCUS showed pathological findings in 11/11 (100%). In particular, according to Rapid Ultrasound in SHock (RUSH) protocol, cardiac hypokinesis was detected in 5/11 (45%) and inferior vena cava dilatation in 3/11 (27%). Peritoneal fluid was reported in 6/11 cases (54%). Lung ultrasound (LUS) evaluation revealed an interstitial syndrome in 11/11 (100%), mainly localized in posterior basal lung segments. We suggest PoCUS as a useful tool in the first evaluation of children with suspected MIS-C for the initial therapeutic management and the following monitoring of possible cardiovascular deterioration.

Indexed as

ChildrenLUSMIS-CPoCUSSARS-CoV-2 infection

Identifiers

PMID34495434
PMCPMC8424151
OpenAlexW3196587370

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.