ArticleActa diabetologica2022
Is it time to consider depression as a major complication of type 2 diabetes? Evidence from a large population-based cohort study.
Article in Acta diabetologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- The relationship between fasting blood glucose, glycated hemoglobin, fructosamine, and depression in patients with type 2 diabetes mellitus in South Korea: a secondary analysis of the Korea National Health and Nutrition Examination Survey VIII-2 (2020) data.Journal of Korean biological nursing science · 2026Article
- Implementing a federated regional diabetes register in a decentralized health system: implications for healthcare organization and the European Health Data Space.Frontiers in public health · 2026Article
- Patient-Reported Outcome Measures in Adults with Type 2 Diabetes-With a Focus on Older Populations: An AI-Assisted Rapid Review of Use and Implementation in Clinical and Organizational Practice.Healthcare (Basel, Switzerland) · 2025Review
- Article
- Trends in Depression Among Hospitalized Patients with Type 2 Diabetes in Spain (2017-2023): A Population-Based Analysis with a Focus on Sex Differences and In-Hospital Outcomes.Journal of clinical medicine · 2025Article
- Protocol for the diabetes, distress and disparities (3D) study: an explanatory sequential mixed-methods design.BMJ open · 2025Article
- The interface of depression and diabetes: treatment considerations.Translational psychiatry · 2025Review
- Comorbidity of Depression and Diabetes: A Literature Review on Systemic Flaws in Healthcare and the Benefits of Collaborative Diagnosis and Treatment in Primary Care Settings.Current diabetes reviews · 2025Review
- Clinical Health Psychology Perspectives in Diabetes Care: A Retrospective Cohort Study Examining the Role of Depression in Adherence to Visits and Examinations in Type 2 Diabetes Management.Healthcare (Basel, Switzerland) · 2024Article
- The impact of a diabetes diagnosis on health and well-being: Findings from the English Longitudinal Study of Ageing.Journal of diabetes · 2024Article
- Reconsidering the role of depression and common psychiatric disorders as partners in the type 2 diabetes epidemic.World journal of diabetes · 2024Article
- Depression and type 2 diabetes risk: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Insomnia and common mental disorder among patients with pre-existing chronic non-communicable diseases in southern Ethiopia: a survey during COVID-19 pandemic.Frontiers in psychiatry · 2023Article
- Emergency department accesses for diabetes-related complications during COVID-19 pandemic in people with type 2 diabetes and depression.Acta diabetologica · 2022Article
- Diabetes and COVID-19: Short- and Long-Term Consequences.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2022Review
- The interface of COVID-19, diabetes, and depression.Discover mental health · 2022Review
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Authors and funding
11 authors.
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Abstract
aimsDepression in type 2 diabetes may heavily affect the course of the disease. In this study, we investigated, among new cases with type 2 diabetes, the incidence and clinical predictors of depression and determined the extent to which depression constitutes a risk factor for acute and long-term diabetes complications and mortality.
methodsIn this population-based retrospective cohort study, incident cases of type 2 diabetes without a prior history of depression were identified from the administrative databases of the Emilia-Romagna Region, Italy, between 2008 and 2017 and followed up until 2020. Logistic regression models were used to identify the predictors of depression. Cox regression models were used to estimate the risk of acute complications over three years, and the risk of long-term complications and mortality over ten years.
resultsIncident cases with type 2 diabetes were 30,815, of whom 5146 (16.7%) developed depression. The predictors of depression onset were as follows: female sex, age > 65 years, living in rural areas and comorbid diseases. Depression in type 2 diabetes was associated with a 2.3-fold risk of developing acute complications, 1.6-fold risk of developing long-term complications and 2.8-fold mortality risk.
conclusionsOur findings highlight that depression is associated with an increased risk for complications in type 2 diabetes and mortality and should not be neglected. Therefore, it is important to promote screening activities and introduce targeted and personalized treatment for depression in order to reduce the risk of poor short- and long-term outcomes of diabetes.
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