ArticleIntensive care medicine2021
The 5-year pre- and post-hospitalization treated prevalence of mental disorders and psychotropic medication use in critically ill patients: a Canadian population-based study.
Article in Intensive care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Phenomenological Study on the Lived Experience of Patients After Major Cardiac Surgery in Intensive Care Units.Nursing in critical care · 2025Article
- Mental health status among COVID-19 patients survivors of critical illness in Saudi Arabia: A 6-month follow-up questionnaire study.World journal of clinical cases · 2024Article
- Psychotropic prescribing after hospital discharge in survivors of critical illness, a retrospective cohort study (2012-2019).Journal of the Intensive Care Society · 2024Article
- Risk factors for dementia in older intensive care unit (ICU) survivors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Pre-intensive care unit use of selective serotonin reuptake inhibitors and mortality in critically ill adults with mental disorders: analysis from the MIMIC-IV database.Translational psychiatry · 2023Article
- Epidemiological and clinical perspectives of long COVID syndrome.American journal of medicine open · 2023Article
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- Incidence and risk factors of mental illness among the spouses of patients with sepsis: a population-based cohort study.Intensive care medicine · 2022Article
- Chicken or the egg? Critical illness and mental health.Intensive care medicine · 2021Article
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Authors and funding
20 authors at 7 institutions in 3 countries.
Funding
Abstract
purposeThe interplay between critical illness and mental disorders is poorly understood. The purpose of this study is to measure both the treated prevalence of mental disorders and psychotropic medication use before and after hospitalization and the impact of intensive care unit (ICU) admission on these outcomes.
methodsUsing a population-based administrative database in Manitoba, Canada, 49,439 ICU patients admitted between 2000 and 2012 were compared to two matched comparison groups (hospitalized; n = 146,968 and general population; n = 141,937). Treated prevalence of mental disorders and psychotropic medication prescriptions were measured in the 5-year periods before and after the hospitalization. Multivariable models compared adjusted prevalence ratios (APRs) between populations.
resultsThe 5-year treated mental disorder prevalence in the ICU population increased from 41.5% pre-hospitalization to 55.6% post-hospitalization. Compared to non-ICU hospitalized patients, the adjusted treated mental disorder prevalence in ICU patients was lower prior to hospitalization (1-year APR 0.94, 95% CI 0.92-0.97, p < 0.0001; 5-year APR 0.99, 95% CI 0.98-1.00, p = 0.1), but higher following discharge (1-year APR 1.08, 95% CI 1.05-1.11, p < 0.0001, 5-year APR 1.03, 95% CI 1.01-1.05, p < 0.0001). A high proportion of ICU patients received antidepressant, anxiolytic and sedative-hypnotic prescriptions before and after their hospitalization. In multivariable analyses, ICU exposure was associated with an increase in mood, anxiety and psychotic disorders, and sedative-hypnotics use (p < 0.0001 for all Time × Group interactions).
conclusionsDuring the 5 years after admission to ICU, there is a significant increase in treated prevalence of mental disorders and psychotropic medication use compared to the 5 years prior to ICU and compared to general population and hospital cohorts. Prevention and intervention programs that identify and treat mental disorders among survivors of critical illness warrant further study.
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