Evidence map›Paper›PMID 34495335›Full record

ReviewBiochemical Society transactions2021

Studying bacterial chemosensory array with CryoEM.

Zhuan Qin, Peijun Zhang

Open access · hybridAbstract readReview
In one paragraph

Review in Biochemical Society transactions, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. ThemBio · 2026
    Article
  2. Review
  3. Structure and signaling mechanism ofbioRxiv : the preprint server for biology · 2026
    Article
  4. Microorganisms · 2025
    Review
  5. Article
  6. Recent structural advances in bacterial chemotaxis signalling.Current opinion in structural biology · 2023
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Zhuan QinDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, U.K.
Peijun ZhangDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, U.K.ORCID 0000-0003-1803-691X
Centre for Human Genetics · GB

Funding

X-Ray Core P50GM082251 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ENGELMAN, ALAN N. · 2007 to 2018
$48.1M
Structure and function of membrane receptor signaling complex in bacterial chemotR01GM085043 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHANG, PEIJUN · 2009 to 2013
$1.4M
Biotechnology and Biological Sciences Research Council BB/S003339/1NIGMS NIH HHS P50 GM082251NIGMS NIH HHS R01 GM085043Wellcome Trust 206422/Z/17/Z
6 · The paper itself

Abstract

Bacteria direct their movement in respond to gradients of nutrients and other stimuli in the environment through the chemosensory system. The behavior is mediated by chemosensory arrays that are made up of thousands of proteins to form an organized array near the cell pole. In this review, we briefly introduce the architecture and function of the chemosensory array and its core signaling unit. We describe the in vivo and in vitro systems that have been used for structural studies of chemosensory array by cryoEM, including reconstituted lipid nanodiscs, 2D lipid monolayer arrays, lysed bacterial ghosts, bacterial minicells and native bacteria cells. Lastly, we review recent advances in structural analysis of chemosensory arrays using state-of-the-art cryoEM and cryoET methodologies, focusing on the latest developments and insights with a perspective on current challenges and future directions.

Indexed as

ChemotaxisCryoelectron MicroscopyElectron Microscope TomographyEscherichia coliEscherichia coli ProteinsHistidine KinaseMethyl-Accepting Chemotaxis ProteinsModels, MolecularProtein MultimerizationSignal TransductioncheA protein, E coliCheW protein, E coliEscherichia coli ProteinsHistidine KinaseMethyl-Accepting Chemotaxis Proteinsbacterial chemotaxischemoreceptor arraycryo-electron tomographycryoEMin-situ structuresubtomogram averaging

Identifiers

PMID34495335
PMCPMC8589424
OpenAlexW3198081347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.