Evidence map›Paper›PMID 34495325›Full record

ReviewBiochemical Society transactions2021

Progress and challenges in understanding the regulation and function of p53 dynamics.

Zhilin Yang, Ryan L Hanson, Eric Batchelor

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemical Society transactions, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Zhilin Yang *Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A.
Ryan L Hanson *Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, U.S.A.
Eric BatchelorDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, U.S.A.ORCID 0000-0003-3870-5615
University of Minnesota · USNational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dynamics of p53 expression provide a mechanism to increase differentiation between cellular stresses and specificity in appropriate responses. Here, we review recent advances in our understanding of the molecular mechanisms regulating p53 dynamics and the functions of the dynamics in the regulation of p53-dependent cell stress responses. We also compare dynamic encoding in the p53 system with that found in other important cell signaling systems, many of which can interact with the p53 network. Finally, we highlight some of the current challenges in understanding dynamic cell signaling within a larger cellular network context.

Indexed as

AnimalsCell Cycle CheckpointsCell ProliferationDNA DamageDNA RepairGene ExpressionGene Expression RegulationHumansKineticsSignal TransductionTranscription FactorsTumor Suppressor Protein p53Transcription FactorsTumor Suppressor Protein p53dynamicsmicroscopyp53signalingsingle cell

Identifiers

PMID34495325
PMCPMC8765192
OpenAlexW3197422639

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.