ArticleThe Journal of experimental medicine2021
Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma.
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Article in The Journal of experimental medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
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26 citing papers in PubMed, 39 citations in OpenAlex.
- Purification and Transcriptomic Characterization of Hypertrophied Hepatic Stellate Cells From CDAHFD Mouse Liver.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Regulation of NTRK2 alternative splicing by PRPF40B controls neural differentiation and synaptic plasticity.Cell death & disease · 2025Article
- Establishment and validation of a diagnostic model for cholangiocarcinoma based on LightGBM machine-learning algorithm.Scientific reports · 2025Article
- Heterozygous pathogenic variants in the splicing factor SF1 lead to a large spectrum of neurodevelopmental disorders.American journal of human genetics · 2025Article
- Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells.Cellular & molecular immunology · 2025Review
- Article
- Autocrine GDF10 Inhibits Hepatic Stellate Cell Activation via BMPR2/ALK3 Receptor to Prevent Liver Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Gut Microbiome and Bile Acid Interactions: Mechanistic Implications for Cholangiocarcinoma Development, Immune Resistance, and Therapy.The American journal of pathology · 2025Review
- Research progress of T cells in cholangiocarcinoma.Frontiers in immunology · 2025Review
- Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes.Nature immunology · 2024Article
- Single-Cell RNA Sequencing in Organ and Cell Transplantation.Biosensors · 2024Review
- Current Perspectives on the Molecular and Clinical Relationships between Primary Biliary Cholangitis and Hepatocellular Carcinoma.International journal of molecular sciences · 2024Review
- Isolation of Primary Mouse Hepatocytes and Non-Parenchymal Cells from a Liver with Precancerous Lesions.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Oncogene-Driven Induction of Orthotopic Cholangiocarcinoma in Mice.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Single-cell analysis of T lymphocytes infiltrating colorectal carcinoma: the dilemma of specificity.Oncoimmunology · 2024Article
- BCL2 Inhibition Reveals a Dendritic Cell-Specific Immune Checkpoint That Controls Tumor Immunosurveillance.Cancer discovery · 2023Article
- Immunology and immunotherapy of cholangiocarcinoma.Nature reviews. Gastroenterology & hepatology · 2023Review
- RELA tunes innate-like interferon I/III responses in human T cells.The Journal of experimental medicine · 2023Article
- Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and Cholangiocarcinoma.Cellular and molecular gastroenterology and hepatology · 2023Review
- Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance.Oncoimmunology · 2023Article
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Authors and funding
36 authors at 7 institutions in 5 countries.
Juliette PailletEquipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale U1138, Université de Paris, Sorbonne Université, Paris, France.ORCID 0000-0001-7118-7165
Céleste PlantureuxEquipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale U1138, Université de Paris, Sorbonne Université, Paris, France.ORCID 0000-0003-4437-0479
Sarah LévesqueEquipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale U1138, Université de Paris, Sorbonne Université, Paris, France.ORCID 0000-0002-0293-0450
Julie Le NaourEquipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale U1138, Université de Paris, Sorbonne Université, Paris, France.ORCID 0000-0002-3749-2171
Gautier StollEquipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale U1138, Université de Paris, Sorbonne Université, Paris, France.ORCID 0000-0002-0862-4139
Allan SauvatEquipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale U1138, Université de Paris, Sorbonne Université, Paris, France.ORCID 0000-0001-7076-8638
Pamela CaudanaInstitut Curie, Paris Sciences et Lettres Research University, Institut National de la Santé et de la Recherche Médicale U932, Paris, France.ORCID 0000-0002-1737-0476
Jimena Tosello BoariInstitut Curie, Paris Sciences et Lettres Research University, Institut National de la Santé et de la Recherche Médicale U932, Paris, France.ORCID 0000-0003-1563-4420
Norma BloyEquipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale U1138, Université de Paris, Sorbonne Université, Paris, France.ORCID 0000-0001-5758-9424
Sylvie LachkarEquipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale U1138, Université de Paris, Sorbonne Université, Paris, France.ORCID 0000-0002-8169-140X
Isabelle MartinsEquipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale U1138, Université de Paris, Sorbonne Université, Paris, France.ORCID 0000-0003-0885-613X
Paule OpolonGustave Roussy Cancer Campus, Villejuif, France.ORCID 0000-0002-9758-1408
Andrea CheccoliInstitut Curie, Paris Sciences et Lettres Research University, Paris, France.ORCID 0000-0002-8290-6310
Agathe DelauneGenoSplice Technology, Paris, France.ORCID 0000-0003-4552-8266
Noémie RobilGenoSplice Technology, Paris, France.ORCID 0000-0002-3918-1406
Pierre de la GrangeGenoSplice Technology, Paris, France.ORCID 0000-0001-6361-1878
Juliette HamrouneInstitut National de la Santé et de la Recherche Médicale U1016, Institut Cochin, Paris, France.ORCID 0000-0002-1812-2853
Franck LetourneurInstitut National de la Santé et de la Recherche Médicale U1016, Institut Cochin, Paris, France.ORCID 0000-0001-9465-4774
Gwennhael AutretUniversité de Paris, Paris Cardiovascular Research Centre, Institut National de la Santé et de la Recherche Médicale U970, Paris, France.ORCID 0000-0001-7335-350X
Patrick S C LeungDivision of Rheumatology/Allergy and Clinical Immunology, University of California, Davis School of Medicine, Davis, CA.ORCID 0000-0001-5862-4316
M Eric GershwinDivision of Rheumatology/Allergy and Clinical Immunology, University of California, Davis School of Medicine, Davis, CA.ORCID 0000-0001-5245-2680
Jie S ZhuDepartment of Chemistry, University of California, Davis, Davis, CA.ORCID 0000-0003-3009-4135
Mark J KurthDepartment of Chemistry, University of California, Davis, Davis, CA.ORCID 0000-0001-8496-6125
Bouchra LekbabyInstitut National de la Santé et de la Recherche Médicale U938, Centre de Recherche Saint-Antoine, Sorbonne Université, Paris, France.ORCID 0000-0001-7247-0165
Jérémy AugustinInstitut National de la Santé et de la Recherche Médicale U938, Centre de Recherche Saint-Antoine, Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Hôpital Henri-Mondor, Département de Pathologie, Paris, France.ORCID 0000-0001-8194-0624
Youra KimDepartment of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.ORCID 0000-0002-9542-0651
Shashi GujarDepartment of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.ORCID 0000-0002-5427-0829
Cédric CoulouarnInstitut National de la Santé et de la Recherche Médicale, Université de Rennes 1, Chemistry, Oncogenesis Stress Signaling, UMR_S 1242, Centre de Lutte contre le Cancer Eugène Marquis, Rennes, France.ORCID 0000-0002-5692-9586
Laura FouassierInstitut National de la Santé et de la Recherche Médicale U938, Centre de Recherche Saint-Antoine, Sorbonne Université, Paris, France.ORCID 0000-0001-6377-5610
Laurence ZitvogelInstitut National de la Santé et de la Recherche Médicale U1015, Université Paris-Saclay, Gustave Roussy Cancer Campus, Villejuif, France.ORCID 0000-0003-1596-0998
Eliane PiaggioCentre d'Investigation Clinique Biothérapie 1428, Institut Curie, Paris, France.ORCID 0000-0002-2455-8442
Chantal HoussetInstitut National de la Santé et de la Recherche Médicale U938, Centre de Recherche Saint-Antoine, Sorbonne Université, Paris, France.ORCID 0000-0001-6469-0651
Patrick SoussanInstitut National de la Santé et de la Recherche Médicale U938, Centre de Recherche Saint-Antoine, Sorbonne Université, Paris, France.ORCID 0000-0003-2706-7371
Maria Chiara MaiuriEquipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale U1138, Université de Paris, Sorbonne Université, Paris, France.ORCID 0000-0001-9760-7674
Guido KroemerEquipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale U1138, Université de Paris, Sorbonne Université, Paris, France.ORCID 0000-0002-9334-4405
Jonathan G PolEquipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale U1138, Université de Paris, Sorbonne Université, Paris, France.ORCID 0000-0002-8355-7562
Inserm · FRUniversity of California, Davis · USInstitut Curie · FRDalhousie University · CAInstitut Gustave Roussy · FRKarolinska University Hospital · SEOncogenesis Stress Signaling · FR
Funding
CIHR
Abstract
Cholangiocarcinoma (CCA) results from the malignant transformation of cholangiocytes. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are chronic diseases in which cholangiocytes are primarily damaged. Although PSC is an inflammatory condition predisposing to CCA, CCA is almost never found in the autoimmune context of PBC. Here, we hypothesized that PBC might favor CCA immunosurveillance. In preclinical murine models of cholangitis challenged with syngeneic CCA, PBC (but not PSC) reduced the frequency of CCA development and delayed tumor growth kinetics. This PBC-related effect appeared specific to CCA as it was not observed against other cancers, including hepatocellular carcinoma. The protective effect of PBC was relying on type 1 and type 2 T cell responses and, to a lesser extent, on B cells. Single-cell TCR/RNA sequencing revealed the existence of TCR clonotypes shared between the liver and CCA tumor of a PBC host. Altogether, these results evidence a mechanistic overlapping between autoimmunity and cancer immunosurveillance in the biliary tract.
Indexed as
AutoimmunityAnimalsBile Duct NeoplasmsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell Line, TumorCholangiocarcinomaCholangitisCytokinesFemaleForkhead Transcription FactorsLiverMiceMice, Inbred C57BLMonitoring, ImmunologicNeoplasms, ExperimentalCytokinesForkhead Transcription FactorsFoxp3 protein, mouse
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