ArticleActa cirurgica brasileira2021
Remote ischemic conditioning improves rat brain antioxidant defense in a time-dependent mechanism.
Article in Acta cirurgica brasileira, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 4 citations in OpenAlex.
- Nephroprotective effect of remote ischemic conditioning on type 2 diabetic rats.Iranian journal of basic medical sciences · 2024Article
- [Forsythiaside B inhibits cerebral ischemia/reperfusion-induced oxidative stress injury in miceNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
purposeTo clarify the best protocol for performing remote ischemic conditioning and to minimize the consequences of ischemia and reperfusion syndrome in brain, the present study aimed to evaluate different time protocols and the relation of the organs and the antioxidant effects of this technique.
methodsThe rat's left femoral artery was clamped with a microvascular clamp in times that ranged from 1 to 5 minutes, according to the corresponding group. After the cycles of remote ischemic conditioning and a reperfusion of 20 minutes, the brain and the left gastrocnemius were collected. The samples were used to measure glutathione peroxidase, glutathione reductase and catalase levels.
resultsIn the gastrocnemius, the 4-minute protocol increased the catalase concentration compared to the 1-minute protocol, but the latter increased both glutathione peroxidase and glutathione reductase compared to the former. On the other hand, the brain demonstrated higher catalase and glutathione peroxidase in 5-minute group, and the 3-minute group reached higher values of glutathione reductase.
conclusionsRemote ischemic conditioning increases brain antioxidant capacity in a time-dependent way, while muscle presents higher protection on 1-minute cycles and tends to decrease its defence with longer cycles of intermittent occlusions of the femoral artery.
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