Evidence map›Paper›PMID 34494935›Full record

ReviewCell adhesion & migration2021

The roles of serotonin in cell adhesion and migration, and cytoskeletal remodeling.

Joe Anand Kumar John Jayakumar, Mitradas M Panicker

Open access · goldAbstract readReview
In one paragraph

Review in Cell adhesion & migration, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Joe Anand Kumar John JayakumarManipal Academy of Higher Education, Manipal, India.ORCID 0000-0003-3414-8188
Mitradas M PanickerNational Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru, India.ORCID 0000-0002-0782-6222
Tata Institute of Fundamental Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serotonin is well known as a neurotransmitter. Its roles in neuronal processes such as learning, memory or cognition are well established, and also in disorders such as depression, schizophrenia, bipolar disorder, and dementia. However, its effects on adhesion and cytoskeletal remodelling which are strongly affected by 5-HT receptors, are not as well studied with some exceptions for e.g. platelet aggregation. Neuronal function is strongly dependent on cell-cell contacts and adhesion-related processes. Therefore the role played by serotonin in psychiatric illness, as well as in the positive and negative effects of neuropsychiatric drugs through cell-related adhesion can be of great significance. In this review, we explore the role of serotonin in some of these aspects based on recent findings.

Indexed as

AnimalsCell AdhesionCell MovementCytoskeletonHumansMental DisordersNeurotransmitter AgentsSerotoninNeurotransmitter AgentsSerotoninantidepressantsantipsychoticscell adhesion and migrationcovid-19cytoskeletal remodelingdevelopmenthomeostasisimmune cellsneuronal cellsplatelet aggregationSerotonin

Identifiers

PMID34494935
PMCPMC8437456
OpenAlexW3198322425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.