Evidence map›Paper›PMID 34494832›Full record

ArticleBiochemistry2021

Substrate Analogues for the Enzyme-Catalyzed Detoxification of the Organophosphate Nerve Agents-Sarin, Soman, and Cyclosarin.

Andrew N Bigley, Steven P Harvey, Tamari Narindoshvili, Frank M Raushel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Andrew N BigleyDepartment of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
Steven P HarveyUS Army DEVCOM-CBC, FCDD-CBR-CC E3400, 5183 Blackhawk Rd. Aberdeen Proving Ground, Aberdeen, Maryland 21010, United States.
Tamari NarindoshviliDepartment of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
Frank M RaushelDepartment of Chemistry, Texas A&M University, College Station, Texas 77843, United States.ORCID 0000-0002-5918-3089
Texas A&M University · USUnited States Army Combat Capabilities Development Command · US

Funding

The Discovery of Novel Metabolic Pathways for the Biosynthesis and Degradation of Complex Carbohydrates within the Human Gut MicrobiomeR35GM139428 · NIGMS · TEXAS A&M UNIVERSITY · PI RAUSHEL, FRANK M. · 2021 to 2025
$2.8M
Enzymatic Hydrolysis of Organophosphate EstersR01GM116894 · NIGMS · TEXAS A&M UNIVERSITY · PI RAUSHEL, FRANK M. · 2017 to 2020
$1.1M
NIGMS NIH HHS R01 GM116894NIGMS NIH HHS R35 GM139428
6 · The paper itself

Abstract

The G-type nerve agents, sarin (GB), soman (GD), and cyclosarin (GF), are among the most toxic compounds known. Much progress has been made in evolving the enzyme phosphotriesterase (PTE) from

Indexed as

AcetylcholinesteraseCatalysisChemical Warfare AgentsHydrolysisNerve AgentsOrganophosphatesOrganophosphorus CompoundsOrganothiophosphorus CompoundsPhosphoric Triester HydrolasesSarinSomanAcetylcholinesteraseChemical Warfare Agentscyclohexyl methylphosphonofluoridateNerve AgentsOrganophosphatesOrganophosphorus CompoundsOrganothiophosphorus CompoundsPhosphoric Triester HydrolasesSarinSoman

Identifiers

PMID34494832
PMCPMC8517911
OpenAlexW3196310051

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.