Observational studyPediatric diabetes2021
Autonomic cardiac regulation during spontaneous nocturnal hypoglycemia in children with type 1 diabetes.
Observational study in Pediatric diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Heart rate variability changes precede nocturnal hypoglycemia in children with type 1 diabetes.Acta diabetologica · 2026Article
- Advances in Electrocardiogram-Based Non-Invasive Blood Glucose Monitoring Technology.Diabetes, obesity & metabolism · 2026Review
- Multimodal Physiological Monitoring Using Novel Wearable Sensors: A Pilot Study on Nocturnal Glucose Dynamics and Meal-Related Cardiovascular Responses.Bioengineering (Basel, Switzerland) · 2026Article
- Changes of the cardiac electrical cycle in type 1 diabetes during hypoglycaemia - a prospective observational study.Frontiers in endocrinology · 2025Observational
- Multisensor Integrated Platform Based on MEMS Charge Variation Sensing Technology for Biopotential Acquisition.Sensors (Basel, Switzerland) · 2024Article
- Predicting risk for nocturnal hypoglycemia after physical activity in children with type 1 diabetes.Frontiers in medicine · 2024Article
- Brain Regulation of Cardiac Function during Hypoglycemia.Metabolites · 2023Review
- Autonomic cardiac regulation during spontaneous nocturnal hypoglycemia in children with type 1 diabetes.Pediatric diabetes · 2021Observational
- Sleep as a window of cardiometabolic health: The potential of digital sleep and circadian biomarkers.Digital healthReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypoglycemia is the most common complication in insulin treated diabetes. Though mostly mild, it can be fatal in rare cases: It is hypothesized that hypoglycemia related QTc prolongation contributes to cardiac arrhythmia.
objectiveTo evaluate influence of nocturnal hypoglycemia on QTc and heart rate variability (HRV) in children with T1D.
methodsChildren and adolescents with T1D for at least 6 months participated in an observational study using continuous glucose monitoring (CGM) and Holter electrocardiogram for five consecutive nights. Mean QTc was calculated for episodes of nocturnal hypoglycemia (<3.7 mmol/L) and compared to periods of the same duration preceding hypoglycemia. HRV (RMSSD, low and high frequency power LF and HF) was analyzed for different 15 min intervals: before hypoglycemia, onset of hypoglycemia, before/after nadir, end of hypoglycemia and after hypoglycemia.
resultsMean QTc during hypoglycemia was significantly longer compared to euglycemia (412 ± 15 vs. 405 ± 18 ms, p = 0.005). HRV changed significantly: RMSSD (from 88 ± 57 to 73 ± 43 ms) and HF (from 54 ± 17 to 47 ± 17nu) decreased from before hypoglycemia to after nadir, while heart rate (from 69 ± 9 to 72 ± 12 bpm) and LF (from 44 ± 17 to 52 ± 21 nu) increased (p = 0.04).
conclusionA QTc lengthening effect of nocturnal hypoglycemia in children with T1D was documented. HRV changes occurred even before detection of nocturnal hypoglycemia by CGM, which may be useful for hypoglycemia prediction.
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