Evidence map›Paper›PMID 34494680›Full record

ArticleThe EMBO journal2021

Photoreceptor nanotubes mediate the in vivo exchange of intracellular material.

Arturo Ortin-Martinez, Nicole E Yan, En Leh Samuel Tsai, Lacrimioara Comanita, Akshay Gurdita, Nobuhiko Tachibana, Zhongda C Liu, Suying Lu, Parnian Dolati, Neno T Pokrajac and 5 more

Open access · hybridAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. The neuroimmune interface in retinal regeneration.Progress in retinal and eye research · 2025
    Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. H-Ras induces exuberantiScience · 2024
    Article
  19. Inter-cellular mRNA Transfer Alters Human Pluripotent Stem Cell State.bioRxiv : the preprint server for biology · 2024
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Arturo Ortin-MartinezDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0003-0492-6604
Nicole E Yan *Donald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0003-3614-8501
En Leh Samuel Tsai *Donald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0001-7553-9770
Lacrimioara ComanitaDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0003-4066-7072
Akshay GurditaDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Nobuhiko TachibanaDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Zhongda C LiuDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Suying LuLunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health Systems, Toronto, ON, Canada.
Parnian DolatiDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Neno T PokrajacDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0002-0548-779X
Ahmed El-SehemyDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Philip E B NickersonDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Carol SchuurmansDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.ORCID 0000-0003-3567-0058
Rod BremnerDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-9184-7212
Valerie A WallaceDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0003-3721-9017
University Health Network · CAMount Sinai Hospital · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence suggests that intracellular molecules and organelles transfer between cells during embryonic development, tissue homeostasis and disease. We and others recently showed that transplanted and host photoreceptors engage in bidirectional transfer of intracellular material in the recipient retina, a process termed material transfer (MT). We used cell transplantation, advanced tissue imaging approaches, genetic and pharmacologic interventions and primary cell culture to characterize and elucidate the mechanism of MT. We show that MT correlates with donor cell persistence and the accumulation of donor-derived proteins, mitochondria and transcripts in acceptor cells in vivo. MT requires cell contact in vitro and is associated with the formation of stable microtubule-containing protrusions, termed photoreceptor nanotubes (

Indexed as

ActinsAnimalsBiological TransportCell SurvivalExtracellular VesiclesFemaleGreen Fluorescent ProteinsHumansMaleMiceMice, Inbred C57BLMice, TransgenicMitochondriaPhotoreceptor Cells, VertebrateRetinaRetinoblastomaActinsGnat1 protein, mouseGreen Fluorescent Proteinsrho GTP-Binding ProteinsTransducincell therapymaterial transfernanotubesphotoreceptorsretina

Identifiers

PMID34494680
PMCPMC8591540
OpenAlexW3198409310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.