Evidence map›Paper›PMID 34494545›Full record

ArticleeLife2021

Telomere length is associated with growth in children in rural Bangladesh.

Audrie Lin, Andrew N Mertens, Benjamin F Arnold, Sophia Tan, Jue Lin, Christine P Stewart, Alan E Hubbard, Shahjahan Ali, Jade Benjamin-Chung, Abul K Shoab and 15 more

Registry-linked trialAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01590095 (WASH Benefits Bangladesh), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01590095 naunknown statusnot on this map

WASH Benefits Bangladesh: A Cluster Randomized Controlled Trial of the Benefits of Water, Sanitation, Hygiene Plus Nutrition Interventions on Child Growth

TypeinterventionalSponsorInternational Centre for Diarrhoeal Disease Research, BangladeshRan2012 to 2022Enrolled5,040ConditionsMalnutrition, Diarrhea, Child DevelopmentArmsWater quality, Sanitation, Hand washing, Water quality, Sanitation, Hand washing (Combined WASH), Nutrition
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Audrie LinDivision of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-3877-3469
Andrew N MertensDivision of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-1050-6721
Benjamin F ArnoldFrancis I. Proctor Foundation, University of California San Francisco, San Francisco, United States.ORCID 0000-0001-6105-7295
Sophia TanDivision of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, United States.
Jue LinDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States.
Christine P StewartDepartment of Nutrition, University of California, Davis, Davis, United States.
Alan E HubbardDivision of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, United States.
Shahjahan AliInfectious Disease Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.ORCID 0000-0003-3883-1208
Jade Benjamin-ChungDepartment of Epidemiology & Population Health, Stanford University, Stanford, United States.
Abul K ShoabInfectious Disease Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Md Ziaur RahmanInfectious Disease Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Syeda L FamidaInfectious Disease Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Md Saheen HossenInfectious Disease Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Palash MutsuddiInfectious Disease Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Salma AktherInfectious Disease Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Mahbubur RahmanInfectious Disease Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Leanne UnicombInfectious Disease Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Ruchira Tabassum NavedHealth System and Population Studies Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Md Mahfuz Al MamunHealth System and Population Studies Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Kausar ParvinHealth System and Population Studies Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Firdaus S DhabharDepartment of Psychiatry & Behavioral Sciences, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, United States.
Patricia KarigerDivision of Community Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, United States.
Lia Ch FernaldDivision of Community Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, United States.
Stephen P LubyDivision of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, United States.
John M ColfordDivision of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, United States.

Funding

A bench to population epidemiologic approach to investigating the effects of antenatal stress and inflammation on child gut inflammation, growth, and developmentK01AI136885 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI LIN, AUDRIE · 2019 to 2023
$648k
NIAID NIH HHS K01 AI136885
6 · The paper itself

Abstract

Background: Previously, we demonstrated that a water, sanitation, handwashing, and nutritional intervention improved linear growth and was unexpectedly associated with shortened childhood telomere length (TL) (Lin et al., 2017). Here, we assessed the association between TL and growth. Methods: We measured relative TL in whole blood from 713 children. We reported differences between the 10th percentile and 90th percentile of TL or change in TL distribution using generalized additive models, adjusted for potential confounders. Results: In cross-sectional analyses, long TL was associated with a higher length-for-age Z score at age 1 year (0.23 SD adjusted difference in length-for-age Z score [95% CI 0.05, 0.42; FDR-corrected p-value = 0.01]). TL was not associated with other outcomes. Conclusions: Consistent with the Funding: Funded by the Bill and Melinda Gates Foundation. Clinical trial number: NCT01590095.

Indexed as

Child DevelopmentTelomere HomeostasisBangladeshChild, PreschoolCross-Sectional StudiesFemaleHumansInfantInfant, NewbornMaleRural PopulationTelomerechilddevelopmental origins of healthdiseaseepidemiologyglobal healthgrowthhumanlow-incomepediatric populationtelomere length

Identifiers

PMID34494545
PMCPMC8494482

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.