Evidence map›Paper›PMID 34494467›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2021

Sensory neuron inositol 1,4,5-trisphosphate receptors contribute to chronic mechanoreflex sensitization in rats with simulated peripheral artery disease.

Korynne S Rollins, Alec L E Butenas, Auni C Williams, Steven W Copp

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Sex-dependent attenuating effects of capsaicin administration on the mechanoreflex in healthy rats.American journal of physiology. Heart and circulatory physiology · 2023
    Article
  3. Bradykinin 2 receptors contribute to the exaggerated exercise pressor reflex in a rat model of simulated peripheral artery disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Korynne S RollinsDepartment of Kinesiology, Kansas State University, Manhattan, Kansas.
Alec L E ButenasDepartment of Kinesiology, Kansas State University, Manhattan, Kansas.ORCID 0000-0002-2452-5018
Auni C WilliamsDepartment of Kinesiology, Kansas State University, Manhattan, Kansas.
Steven W CoppDepartment of Kinesiology, Kansas State University, Manhattan, Kansas.
Kansas State University · US

Funding

Exercise Pressor Reflex Dysfunction in Heart Failure: Mechanisms and TreatmentR01HL142877 · NHLBI · KANSAS STATE UNIVERSITY · PI COPP, STEVEN W · 2018 to 2021
$1.2M
Mechanistic bases for the exaggerated mechanoreflex in peripheral arterial diseaseF31HL154779 · NHLBI · KANSAS STATE UNIVERSITY · PI ROLLINS, KORYNNE SIERRA · 2020 to 2020
$32k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F31HL154779HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL142877NHLBI NIH HHS F31 HL154779NHLBI NIH HHS R01 HL142877
6 · The paper itself

Abstract

The mechanoreflex is exaggerated in patients with peripheral artery disease (PAD) and in a rat model of simulated PAD in which a femoral artery is chronically (∼72 h) ligated. We found recently that, in rats with a ligated femoral artery, blockade of thromboxane A

Indexed as

Mechanotransduction, CellularMuscle ContractionReflexAnimalsDisease Models, AnimalFemoral ArteryInositol 1,4,5-Trisphosphate ReceptorsLigationMaleMechanoreceptorsMuscle, SkeletalPeripheral Arterial DiseaseRatsRats, Sprague-DawleyReceptors, Thromboxane A2, Prostaglandin H2Inositol 1,4,5-Trisphosphate ReceptorsReceptors, Thromboxane A2, Prostaglandin H2blood pressureexercise pressor reflexsensory neurons

Identifiers

PMID34494467
PMCPMC8616625
OpenAlexW3198665186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.