Evidence map›Paper›PMID 34494308›Full record

ArticleJournal of leukocyte biology2022

Mitofusin-2 regulates leukocyte adhesion and β2 integrin activation.

Wei Liu, Alan Y Hsu, Yueyang Wang, Tao Lin, Hao Sun, Joel S Pachter, Alex Groisman, Matthew Imperioli, Fernanda Wajnsztajn Yungher, Liang Hu and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of leukocyte biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. CFTR dictates monocyte adhesion by facilitating integrin clustering but not activation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Review
  4. Targeting Neutrophil βBiomolecules · 2023
    Review
  5. Nexinhib20 Inhibits Neutrophil Adhesion and βJournal of immunology (Baltimore, Md. : 1950) · 2022
    Article
  6. Review
  7. Roles of mitochondria in neutrophils.Frontiers in immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Wei LiuDepartment of Immunology, School of Medicine, UConn Health, Farmington, Connecticut, USA.
Alan Y HsuDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.
Yueyang WangDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.
Tao LinDepartment of Immunology, School of Medicine, UConn Health, Farmington, Connecticut, USA.
Hao SunDepartment of Medicine, University of California, San Diego, La Jolla, California, USA.
Joel S PachterDepartment of Immunology, School of Medicine, UConn Health, Farmington, Connecticut, USA.
Alex GroismanDepartment of Physics, University of California San Diego, La Jolla, California, USA.
Matthew ImperioliDepartment of Neurology, UConn Health, Farmington, Connecticut, USA.
Fernanda Wajnsztajn YungherDepartment of Neurology, UConn Health, Farmington, Connecticut, USA.
Liang HuCardiovascular Institute of Zhengzhou University, Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Penghua WangDepartment of Immunology, School of Medicine, UConn Health, Farmington, Connecticut, USA.
Qing DengDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.
Zhichao FanDepartment of Immunology, School of Medicine, UConn Health, Farmington, Connecticut, USA.
UConn Health · USPurdue University West Lafayette · USUniversity of California, San Diego · USFirst Affiliated Hospital of Zhengzhou University · CN

Funding

Role of microRNAs in neutrophil migrationR35GM119787 · NIGMS · PURDUE UNIVERSITY · PI Qing Deng · 2016 to 2026
$4.9M
Molecular mechanism and preclinical translation of beta2 integrin auto-inhibition on neutrophil arrest and inflammationR01HL145454 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI FAN, ZHICHAO · 2019 to 2023
$2.1M
NHLBI NIH HHS R01 HL145454NIGMS NIH HHS R35 GM119787
6 · The paper itself

Abstract

Neutrophils are critical for inflammation and innate immunity, and their adhesion to vascular endothelium is a crucial step in neutrophil recruitment. Mitofusin-2 (MFN2) is required for neutrophil adhesion, but molecular details are unclear. Here, we demonstrated that β

Indexed as

CD18 AntigensNeutrophilsCell AdhesionNeutrophil InfiltrationN-Formylmethionine Leucyl-PhenylalanineCD18 AntigensN-Formylmethionine Leucyl-Phenylalanineactin polymerizationCD87HL60Mitoifusin-2Neutrophil adhesionneutrophil maturationβ2 integrin activation

Identifiers

PMID34494308
PMCPMC8901796
OpenAlexW3197866156

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.