ArticleArchives of gynecology and obstetrics2022
Investigation of vascular endothelial growth factor (VEGF) polymorphism in patients with idiopathic heavy menstrual bleeding.
Article in Archives of gynecology and obstetrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed, 1 citations in OpenAlex.
- FivePharmacogenomics and personalized medicine · 2026Article
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2 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate whether there is a relationship between the VEGF polymorphisms and idiopathic heavy menstrual bleeding (HMB-E)Query.
methodsSixty-five patients diagnosed with HMB-E according to the FIGO classification system and 65 female healthy volunteers were included in the study. The polymorphic regions rs699947 (- 2578C > A), rs1570360 (- 1154G > A), rs2010963 (+ 405G > C), rs3025039 (+ 936C > T), rs25648 (c534C > T) in the VEGF were detected using Next Generation DNA Sequencing method.
resultsThe - 2578C > A polymorphism CC genotype, CA + AA genotypes, and C allele, as well as the - 1154G > A polymorphism AA genotype, and A allele were associated with increased risk of HMB-E (p < 0.05 for all). However, no statistically significant difference was found between the patient group and the control group in terms of genotype and allele distributions in the 405G > C, + 936C > T, c534C > T polymorphic regions (p > 0.05 for all). While the - 2578/ - 1154/ + 405/c534 AGGC haplotype decreased the risk of HMB-E, the CAGC haplotype was found to increase the risk of HMB-E.
conclusionVEGF - 2578C > A and - 1154G > A polymorphisms were significantly associated with the risk of HMB-E in the Turkish population.
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