ArticleThe Journal of nutrition2021
Dietary Protein Intake Is Positively Associated with Appendicular Lean Mass and Handgrip Strength among Middle-Aged US Adults.
Article in The Journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 20 citations in OpenAlex.
- Meals Containing Equivalent Total Protein from Foods Providing Complete, Complementary, or Incomplete Essential Amino Acid Profiles do not Differentially Affect 24-h Skeletal Muscle Protein Synthesis in Healthy, Middle-Aged Women.The Journal of nutrition · 2024Trial
- Associations of dietary patterns, dietary motivations, and nutritional status with skeletal muscle mass in Chinese older adults: A structural equation modeling study.International journal of nursing sciences · 2026Article
- Socioeconomic Disparities in Cardiovascular Health: A Cross-Sectional Analysis Unpacking the Sequential Mediation Roles of Protein Intake and Handgrip Strength.Healthcare (Basel, Switzerland) · 2026Article
- Determinants of Liver Steatosis Progression in Chinese Children: A Prospective Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Sex differences in the associations of dietary protein intake with lean mass and grip strength in children and adolescents.Journal of the International Society of Sports Nutrition · 2025Article
- Associations of cardiorespiratory fitness and muscle strength during pregnancy with metabolic health outcomes and inflammatory parameters at 1-year postpartum in women after gestational diabetes.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Association of habitual diet with skeletal muscle composition in a cross-sectional, population-based imaging study.Nutrition journal · 2025Article
- Protein Intake and Diet Quality Mediate the Relationship Between Sleep and Handgrip Strength in Adults in the HANDLS Study.Nutrients · 2025Article
- Impact of segmental body composition on metabolicFrontiers in endocrinology · 2025Article
- The Association of Isocaloric Substitution of Dietary Protein in Middle Age with Muscle Mass and Strength in Old Age: The Hordaland Health Study.Current developments in nutrition · 2024Article
- Association Between Dietary Fiber Intake and Low Muscle Strength Among Korean Adults.Clinical nutrition research · 2024Article
- Dietary vitamin K intake in relation to skeletal muscle mass and strength among adults: a cross-sectional study based on NHANES.Frontiers in nutrition · 2024Article
- Nutritional Interventions: Dietary Protein Needs and Influences on Skeletal Muscle of Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Review
- Does Self-Perceived Diet Quality Align with Nutrient Intake? A Cross-Sectional Study Using the Food Nutrient Index and Diet Quality Score.Nutrients · 2023Article
- Association between dietary protein intake, diet quality and diversity, and obesity among women of reproductive age in Kersa, Ethiopia.Frontiers in public health · 2023Article
- Public Health Need, Molecular Targets, and Opportunities for the Accelerated Development of Function-Promoting Therapies: Proceedings of a National Institute on Aging Workshop.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Body composition of the upper limb associated with hypertension, hypercholesterolemia, and diabetes.Frontiers in endocrinology · 2022Article
- Association of Dietary Protein Intake and Grip Strength Among Adults Aged 19+ Years: NHANES 2011-2014 Analysis.Frontiers in nutrition · 2022Article
- The Roles of Carbohydrate Response Element Binding Protein in the Relationship between Carbohydrate Intake and Diseases.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSarcopenia, a progressive loss of skeletal muscle mass and strength, can begin in the 4th decade of life. Protein intake predicts skeletal muscle mass and strength among older adults, but knowledge of similar associations among middle-aged adults is lacking.
objectivesWe aimed to assess associations between protein intake and skeletal muscle mass, characterized by appendicular lean mass adjusted for BMI [in kg/m2 (ALMBMI)], and muscle strength, represented by handgrip strength adjusted for BMI (GSMAXBMI), among middle-aged adults.
methodsWe analyzed cross-sectional data from 1209 men and 1208 women aged 40-59 y in the 2011-2014 NHANES. Protein intake per kilogram actual body weight (BW), assessed by two 24-h recalls, was examined as continuous and categorical parameters [low (<RDA, 0.8 g/kg BW), moderate (≥RDA, <1.2 g/kg BW), and high (≥1.2 g/kg BW)]. ALM was measured using DXA, and GSMAX was measured using handgrip dynamometer. "Low lean mass" and "weakness" were defined using NIH criteria for ALMBMI and GSMAXBMI, respectively. Linear and logistic regression models were performed.
resultsAmong middle-aged adults, 15.6% of men and 13.4% of women had low lean mass and 3.5% of men and 2.3% of women exhibited weakness. Protein intakes per kilogram BW were positively associated with ALMBMI and GSMAXBMI among men and women after adjustment for age, race/Hispanic origin, physical activity, and self-rated health. Compared with the moderate protein group, the high protein group had a higher GSMAXBMI and the low protein group had a lower GSMAXBMI among men and women. The low protein group had a lower ALMBMI (women) and had a higher OR for low lean mass (men) compared with the moderate protein group.
conclusionsHigher protein intakes were associated with greater ALMBMI and GSMAXBMI in this representative sample of US middle-aged adults. Our findings highlight the need for further research on dietary protein as a potential modifying factor of sarcopenia risk in middle age.
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