ArticleBMJ open sport & exercise medicine2021
Fidelity, tolerability and safety of acute high-intensity interval training after hospitalisation for COVID-19: a randomised cross-over trial.
Article in BMJ open sport & exercise medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Rehabilitation and COVID-19: systematic review by Cochrane Rehabilitation.European journal of physical and rehabilitation medicine · 2023Pooled it
- Evidence-based position paper on physical and rehabilitation medicine professional practice for persons with COVID-19, including post COVID-19 condition: the European PRM position (UEMS PRM Section).European journal of physical and rehabilitation medicine · 2023Guideline
- Physical therapy rehabilitation after hospital discharge in patients affected by COVID-19: a systematic review.BMC infectious diseases · 2023Pooled it
- The acute and chronic implications of the COVID-19 virus on the cardiovascular system in adults: A systematic review.Progress in cardiovascular diseasesPooled it
- Impact of a 12-week high-intensity interval training intervention on cardiac structure and function after COVID-19 at 12-month follow-up.Experimental physiology · 2026Trial
- Feasibility of an unsupervised aerobic exercise training program for participants with persistent symptoms after SARS-CoV-2 infection.Scientific reports · 2025Trial
- Additive benefit of rehabilitation on physical status, symptoms and mental health after hospitalisation for severe COVID-19 pneumonia.BMJ open respiratory research · 2023Trial
- The Effect of Physiotherapy on Dyspnea, Muscle Strength and Functional Status in Patients with Long COVID Syndrome.Journal of personalized medicine · 2024Article
- Medium- to long-term health condition of patients post-COVID-19, exercise intolerance and potential mechanisms: A narrative review and perspective.SAGE open medicine · 2024Review
- Feasibility and Safety of Early Post-COVID-19 High-Intensity Gait Training: A Pilot Study.Journal of clinical medicine · 2023Article
- Enhanced Gait Recovery in Chronic Post-COVID-19 Stroke: The Role of Combined Physical Rehabilitation.Reports (MDPI) · 2023Article
- The quality and pattern of rehabilitation interventions prescribed for post-COVID-19 infection patients: A systematic review andPreventive medicine reports · 2023Review
- Article
- Exercise and COVID-19: exercise intensity reassures immunological benefits of post-COVID-19 condition.Frontiers in physiology · 2023Review
- Fidelity and tolerability of two high-intensity interval training protocols in patients with COPD: a randomised cross-over pilot study.BMJ open sport & exercise medicine · 2023Article
- Effects of Aerobic Training in Patients with Subacute COVID-19: A Randomized Controlled Feasibility Trial.International journal of environmental research and public health · 2022Article
- Rehabilitation and COVID-19: update of the rapid living systematic review by Cochrane Rehabilitation Field as of October 31st, 2021.European journal of physical and rehabilitation medicine · 2022Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesMany patients with COVID-19 suffer from persistent symptoms, many of which may potentially be reversed by high-intensity interval training (HIIT). Yet, the safety and tolerability of HIIT after COVID-19 is controversial. This study aimed to investigate the fidelity, tolerability and safety of three different HIIT protocols in individuals that had recently been hospitalised due to COVID-19.
methodsThe study was a randomised cross-over trial. We compared three supervised HIIT protocols (4×4, 6×1, 10-20-30) in 10 individuals recently discharged after hospitalisation for severe COVID-19. Each HIIT protocol had a duration of 38 min and was performed with a 1-week washout between them. Outcomes included adverse events, exercise training intensity and tolerability assessed by the Likert scale (1-10).
resultsAll 10 participants aged 61 (mean, SD 8) years (5 males) completed all three HIIT protocols with no adverse events. High intensities were achieved in all three protocols, although they differed in terms of time spent with a heart rate ≥85% of maximum (mean (SD); 4×4: 13.7 (6.4) min; 10-20-30: 12.1 (3.8) min; 6×1: 6.1 (5.6) min; p=0.03). The three protocols were all well tolerated with similar Likert scale scores (mean (SD); 4×4: 8 (2), 10-20-30: 8 (2), 6×1: 9 (2), p=0.72).
conclusionOur findings indicate that recently hospitalised individuals for severe COVID-19 may safely tolerate acute bouts of supervised HIIT as per protocol. This warrants future studies testing the potential of regular HIIT as a rehabilitation strategy in this context.
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