ReviewPediatric research2022
Vital signs as physiomarkers of neonatal sepsis.
Review in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 68 citations in OpenAlex.
- Impact of race on heart rate characteristics monitoring in very low birth weight infants.Pediatric research · 2023Trial
- Depressed heart rate variability predicts adverse neonatal events and outcomes, with important caveats.Pediatric research · 2026Article
- The Peripheral(-Muscle) Oxygenation and Perfusion Score (POP-Score): A New Non-Invasive Tool Associated with Elevations in C-Reactive Protein Levels in Neonates.Diagnostics (Basel, Switzerland) · 2026Article
- Millimeter-Wave MIMO radar for contactless neonatal heart-rate assessment: performance under common resuscitation-related maneuvers and feasibility in clinical workflow.Frontiers in pediatrics · 2026Article
- Transforming neonatal care through informatics: A review of artificial intelligence, data, and implementation considerations.Seminars in perinatology · 2025Review
- Blood cultures and predicting positivity in extremely preterm infants admitted to an outborn level IV NICU.BMC pediatrics · 2025Observational
- AI models in clinical neonatology: a review of modeling approaches and a consensus proposal for standardized reporting of model performance.Pediatric research · 2025Review
- Automated Deep Learning Approach for Post-Operative Neonatal Pain Detection and Prediction through Physiological Signals.Proceedings. IEEE International Symposium on Computer-Based Medical Systems · 2025Article
- The Measurement of Vital Signs in Pediatric Patients by Lifelight Software in Comparison to the Standard of Care: Protocol for the VISION-Junior Observational Study.JMIR research protocols · 2025Observational
- Enhancing bronchopulmonary dysplasia prediction in preterm infants using artificial intelligence and multimodal data integration.Frontiers in pediatrics · 2025Review
- Day-to-day dynamics of fetal heart rate variability to detect chorioamnionitis in preterm premature rupture of membranes.PloS one · 2025Article
- NeoVault: empowering neonatal research through a neonate data hub.BMC pediatrics · 2024Article
- Metabolic trade-offs in Neonatal sepsis triggered by TLR4 and TLR1/2 ligands result in unique dysfunctions in neural breathing circuits.Brain, behavior, and immunity · 2024Article
- Urinary tract infections in very premature neonates: the definition dilemma.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Heart rate and oxygen saturation patterns in very low birth weight infants with early onset sepsis and histologic chorioamnionitis.Journal of neonatal-perinatal medicine · 2024Article
- Neuromonitoring in neonatal critical care part II: extremely premature infants and critically ill neonates.Pediatric research · 2023Review
- Cardiorespiratory signature of neonatal sepsis: development and validation of prediction models in 3 NICUs.Pediatric research · 2023Article
- Respiratory Rate Extraction from Neonatal Near-Infrared Spectroscopy Signals.Sensors (Basel, Switzerland) · 2023Article
- Global, regional, and national burden of neonatal sepsis and other neonatal infections, 1990-2019: findings from the Global Burden of Disease Study 2019.European journal of pediatrics · 2023Article
- Artificial and human intelligence for early identification of neonatal sepsis.Pediatric research · 2023Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neonatal sepsis accounts for significant morbidity and mortality, particularly among premature infants in the Neonatal Intensive Care Unit. Abnormal vital sign patterns serve as physiomarkers of sepsis and provide early warning of illness before overt clinical decompensation. The systemic inflammatory response to pathogens signals the autonomic nervous system, leading to changes in temperature, respiratory rate, heart rate, and blood pressure. In infants with comorbidities of prematurity, vital sign abnormalities often occur in the absence of infection, which confounds sepsis diagnosis. This review will cover the mechanisms of vital sign changes in neonatal sepsis, including the cholinergic anti-inflammatory pathway mediated by the vagus nerve, which is critical to the host response to infectious and inflammatory insults. We will also review the clinical implications of vital sign changes in neonatal sepsis, including their use in early warning scores and systems to direct clinicians to the bedside of infants with physiologic changes that might be due to sepsis. IMPACT: This manuscript summarizes and reviews the relevant literature on the physiological manifestations of neonatal sepsis and how we monitor and analyze these through vital signs and advanced analytics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.