Evidence map›Paper›PMID 34493790›Full record

ArticleCommunications biology2021

Probiotic Bifidobacterium longum supplied with methimazole improved the thyroid function of Graves' disease patients through the gut-thyroid axis.

Dongxue Huo, Chaoping Cen, Haibo Chang, Qianying Ou, Shuaiming Jiang, Yonggui Pan, Kaining Chen, Jiachao Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Dongxue Huo *Department of Endocrinology, Hainan General Hospital, School of Food Science and Engineering, Hainan University, Haikou, China.
Chaoping Cen *Department of Endocrinology, Hainan General Hospital, School of Food Science and Engineering, Hainan University, Haikou, China.
Haibo ChangDepartment of Endocrinology, Hainan General Hospital, School of Food Science and Engineering, Hainan University, Haikou, China.
Qianying OuDepartment of Endocrinology, Hainan General Hospital, School of Food Science and Engineering, Hainan University, Haikou, China.
Shuaiming JiangKey Laboratory of Food Nutrition and Functional Food of Hainan Province, Haikou, China.
Yonggui PanKey Laboratory of Food Nutrition and Functional Food of Hainan Province, Haikou, China.
Kaining ChenDepartment of Endocrinology, Hainan General Hospital, School of Food Science and Engineering, Hainan University, Haikou, China. kainch@sina.com.
Jiachao ZhangDepartment of Endocrinology, Hainan General Hospital, School of Food Science and Engineering, Hainan University, Haikou, China. zhjch321123@163.com.ORCID 0000-0001-8099-6749
Hainan University · CN

Funding

Hainan Provincial Department of Science and Technology (Department of Science and Technology of Hainan Province) ZDYF2018111
6 · The paper itself

Abstract

Graves' disease (GD) is an autoimmune disorder that frequently results in hyperthyroidism and other symptoms. Here, we designed a 6-month study with patients divided into three treatment groups, namely, methimazole (MI, n = 8), MI + black bean (n = 9) and MI + probiotic Bifidobacterium longum (n = 9), to evaluate the curative effects of probiotics supplied with MI on thyroid function of patients with GD through clinical index determination and intestinal microbiota metagenomic sequencing. Unsurprisingly, MI intake significantly improved several thyroid indexes but not the most important thyrotropin receptor antibody (TRAb), which is an indicator of the GD recurrence rate. Furthermore, we observed a dramatic response of indigenous microbiota to MI intake, which was reflected in the ecological and evolutionary scale of the intestinal microbiota. In contrast, we did not observe any significant changes in the microbiome in the MI + black bean group. Similarly, the clinical thyroid indexes of patients with GD in the probiotic supplied with MI treatment group continued to improve. Dramatically, the concentration of TRAb recovered to the healthy level. Further mechanistic exploration implied that the consumed probiotic regulated the intestinal microbiota and metabolites. These metabolites impacted neurotransmitter and blood trace elements through the gut-brain axis and gut-thyroid axis, which finally improved the host's thyroid function.

Indexed as

AdultAntithyroid AgentsBifidobacterium longumBrain-Gut AxisFemaleGraves DiseaseHumansMaleMethimazoleMiddle AgedProbioticsThyroid GlandAntithyroid AgentsMethimazole

Identifiers

PMID34493790
PMCPMC8423791
OpenAlexW3198226212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.