ArticleScientific reports2021
Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma.
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Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Early-life viral infection generates pathological tissue-resident memory cells that contribute to asthma-like disease.JCI insight · 2026Article
- Regulation of allergies across the body by microbial metabolites.Experimental & molecular medicine · 2026Review
- Advances in the Gut-Lung Axis and Bronchial Asthma: From Mechanisms to Therapeutic Potential.Clinical and translational allergy · 2025Review
- The gut microbiota modulates airway inflammation in allergic asthma through the gut-lung axis related immune modulation: A review.Biomolecules & biomedicine · 2025Review
- Respiratory diseases and the gut microbiota: an updated review.Frontiers in cellular and infection microbiology · 2025Review
- Nitroalkene inhibition of pro-inflammatory macrophage effector function via modulation of signaling metabolite levels.Frontiers in physiology · 2025Article
- Relationship between pediatric asthma and respiratory microbiota, intestinal microbiota: a narrative review.Frontiers in microbiology · 2025Review
- Obesity-related Asthma: A Pathobiology-based Overview of Existing and Emerging Treatment Approaches.American journal of respiratory and critical care medicine · 2024Review
- Sex-based differences in persistent lung inflammation following influenza infection of juvenile outbred mice.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- PD-1 signaling in neonates restrains CD8Mucosal immunology · 2024Article
- The novel molecular mechanism of pulmonary fibrosis: insight into lipid metabolism from reanalysis of single-cell RNA-seq databases.Lipids in health and disease · 2024Review
- Weight Loss Interventions for Adults With Obesity-Related Asthma.The journal of allergy and clinical immunology. In practice · 2024Article
- Respiratory diseases and gut microbiota: relevance, pathogenesis, and treatment.Frontiers in microbiology · 2024Review
- Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics.International journal of molecular sciences · 2023Review
- Application of Metabolomics in Obesity-Related Childhood Asthma Subtyping: A Narrative Scoping Review.Metabolites · 2023Article
- Metabolic Contributions to Pathobiology of Asthma.Metabolites · 2023Review
- Meta-omics profiling of the gut-lung axis illuminates metabolic networks and host-microbial interactions associated with elevated lung elastance in a murine model of obese allergic asthma.Frontiers in microbiomes · 2023Article
- Obesity-related asthma in children and adolescents.The Lancet. Child & adolescent health · 2022Review
- Nitro-Oleic Acid-Mediated Nitroalkylation Modulates the Antioxidant Function of Cytosolic Peroxiredoxin Tsa1 during Heat Stress inAntioxidants (Basel, Switzerland) · 2022Article
- Clinical Characteristics and Management Strategies for Adult Obese Asthma Patients.Journal of asthma and allergy · 2022Review
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 1 country.
Michelle L ManniDivision of Pulmonary Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 15224, USA.
Victoria A HeinrichDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA.
Gregory J BuchanDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA.
James P O'BrienDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA.
Crystal UvalleDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA.
Veronika CechovaDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA.
Adolf KoudelkaDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA.
Dharti UkaniDivision of Pulmonary Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 15224, USA.
Mohamad Rawas-QalajiDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA.
Tim D OuryDepartment of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Renee HartDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA.
Madeline EllgassHealth Sciences Metabolomics and Lipidomics Core, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Steven J MullettDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA.
Merritt L FajtDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Sally E WenzelDepartment of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Fernando HolguinDivision of Pulmonary Sciences and Critical Care, School of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
Bruce A FreemanDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA.
Stacy G WendellDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA. gstacy@pitt.edu.
University of Pittsburgh · USChildren's Hospital of Pittsburgh · USUniversity of Colorado Denver · US
Funding
Anti-Inflammatory Lipid Mediators in AsthmaR01HL132550 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN, HOLGUIN, FERNANDO · 2016 to 2019
$2.9MImmune Mediators of IL-22 Signaling Alter Allergic Airway DiseaseR01HL146445 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MANNI, MICHELLE LYNN · 2020 to 2024
$2.1MPredoctoral Training in Pharmacological Sciences (Resubmission)T32GM133332 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Tija C. Jacob, Francisco Jose Schopfer · 2020 to 2026
$1.8MBringing Untargeted Metabolomics to PittS10OD023402 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GELHAUS, STACY LYNN · 2018 to 2018
$594kThe Effects of Nitrate/Nitrite and Conjugated Linoleic Acid Supplementation on the Obese Asthmatic PathologyR21AI122071 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GELHAUS, STACY LYNN · 2016 to 2017
$426kInteraction Between the Epithelium and Mast Cells in Severe AsthmaF32AI085633 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FAJT, MERRITT LYNN · 2010 to 2012
$132kEvaluating the therapeutic potential of electrophilic fatty acid derivatives for influenza-induced lung injuryF31HL142171 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUCHAN, GREG · 2018 to 2019
$68kNHLBI NIH HHS R01 HL132550NHLBI NIH HHS R01 HL146445NIGMS NIH HHS T32 GM133332NIH HHS F31HL142171NIH HHS F32AI085633NIH HHS R01HL132550NIH HHS R01HL146445NIH HHS R21AI122071NIH HHS S10 OD023402
Abstract
Bile acid profiles are altered in obese individuals with asthma. Thus, we sought to better understand how obesity-related systemic changes contribute to lung pathophysiology. We also test the therapeutic potential of nitro-oleic acid (NO
Indexed as
AdolescentAdultAnimalsAnti-Asthmatic AgentsAntigens, DermatophagoidesAsthmaBile Acids and SaltsDiet, High-FatDrug Evaluation, PreclinicalFatty AcidsFemaleForced Expiratory VolumeGlycocholic AcidHumansLiverLungAnti-Asthmatic AgentsAntigens, DermatophagoidesBile Acids and SaltsCXA-10Fatty AcidsGlycocholic Acidglycoursodeoxycholic acidNitro CompoundsOleic AcidsUrsodeoxycholic Acid
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