Evidence map›Paper›PMID 34493722›Full record

ArticleNature communications2021

Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.

Fangjun Yu, Zhigang Wang, Tianpeng Zhang, Xun Chen, Haiman Xu, Fei Wang, Lianxia Guo, Min Chen, Kaisheng Liu, Baojian Wu

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 85 citations in OpenAlex.

  1. Trial
  2. Article
  3. Berberine alleviates alcoholic liver diseaseactivating intestinal nuclear receptor subfamily 1 group D member 1.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Liver as a nexus of daily metabolic cross talk.International review of cell and molecular biology · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Fangjun Yu *Institute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.
Zhigang Wang *Department of Intensive Care Unit, First Affiliated Hospital of Jinan University, Guangzhou, China.
Tianpeng ZhangInstitute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.
Xun ChenCollege of Pharmacy, Jinan University, Guangzhou, China.
Haiman XuCollege of Pharmacy, Jinan University, Guangzhou, China.
Fei WangCollege of Pharmacy, Jinan University, Guangzhou, China.
Lianxia GuoCollege of Pharmacy, Jinan University, Guangzhou, China.
Min ChenCollege of Pharmacy, Jinan University, Guangzhou, China.
Kaisheng LiuShenzhen People's Hospital, The Second Clinical Medical College of Jinan University, Shenzhen, China. kaisheng_liu@163.com.
Baojian WuInstitute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China. bj.wu@hotmail.com.ORCID 0000-0003-4629-5142
Jinan University · CNGuangzhou University of Chinese Medicine · CNFirst Affiliated Hospital of Jinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of intestine clock in energy homeostasis remains elusive. Here we show that mice with Bmal1 specifically deleted in the intestine (Bmal1

Indexed as

AnimalsARNTL Transcription FactorsCircadian RhythmDiacylglycerol O-AcyltransferaseDietary FatsDiet, High-FatFatty LiverGene Expression RegulationHomeostasisHyperlipidemiasIntestinal MucosaLipid MetabolismMaleMiceMice, Inbred C57BLMice, KnockoutARNTL Transcription FactorsBmal1 protein, mouseDGAT2 protein, mouseDiacylglycerol O-AcyltransferaseDietary FatsNr1d1 protein, mouseNuclear Receptor Subfamily 1, Group D, Member 1PyrrolidinesSR9009ThiophenesTriglycerides

Identifiers

PMID34493722
PMCPMC8423749
OpenAlexW3198051377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.