ArticleNature communications2021
Bio-inspired poly-DL-serine materials resist the foreign-body response.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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Who cites it
37 citing papers in PubMed, 102 citations in OpenAlex.
- A hierarchical, pH-responsive nanocomposite hydrogel platform for synergistic microenvironment reprogramming and attenuation of inflammatory periodontal bone loss.Bioactive materials · 2027Article
- Localized immunomodulation with cytokine-producing cells to mitigate foreign body responses in rodents and a nonhuman primate.Science advances · 2026Article
- A modular hydrogel system with independent control of bioadhesion, fibrosis, and stiffness.Science advances · 2026Article
- Polypeptide-engineered lipid nanoparticles for mRNA delivery with limited immunogenicity.Nature communications · 2026Article
- Chirality Effect on Physical and Biological Properties of Peptide-Based Hydrogels.Gels (Basel, Switzerland) · 2026Review
- Multi-Functional Adaptive Interfaces for Next-Generation Wearable and Implantable Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Innovations in skeletal muscle regeneration: from physiology to bioengineering approaches for repair and restoration.Frontiers in physiology · 2026Review
- Adhesive nonfibrotic bioelectronic interfaces on diverse peripheral nerves for long-term functional neuromodulation.Science advances · 2025Article
- Immunocompatible Elastomer With Enhanced Fibrous Capsule-Resistance and Elasticity by Water-Induced Surface Phase Reconfiguration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Macrophage response to fibrin structure mediated by Tgm2-dependent mitochondrial mechanosensing.Bioactive materials · 2025Article
- Nature-inspired surface modification strategies for implantable devices.Materials today. Bio · 2025Review
- Modulating Neutrophil Extracellular Trap FormationACS central science · 2025Article
- Single-Center Trifunctional Organocatalyst Enables Fast and Controlled Polymerization onACS central science · 2025Article
- Chiral polypeptide hydrogels regulating local immune microenvironment and anti-tumor immune response.Nature communications · 2025Article
- Compliant immune response of silk-based biomaterials broadens application in wound treatment.Frontiers in pharmacology · 2025Review
- Recent Development of Fibrous Hydrogels: Properties, Applications and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Article
- Sericin coats of silk fibres, a degumming waste or future material?Materials today. Bio · 2024Article
- Harnessing Nature-Inspired Catechol Amino Acid to Engineer Sticky Proteins and Bacteria.Small methods · 2024Article
- Stiffness and surface topology of silicone implants competitively mediate inflammatory responses of macrophages and foreign body response.Materials today. Bio · 2024Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implantation-caused foreign-body response (FBR) is a commonly encountered issue and can result in failure of implants. The high L-serine content in low immunogenic silk sericin, and the high D-serine content as a neurotransmitter together inspire us to prepare poly-DL-serine (PSer) materials in mitigating the FBR. Here we report highly water soluble, biocompatible and easily accessible PSer hydrogels that cause negligible inflammatory response after subcutaneous implantation in mice for 1 week and 2 weeks. No obvious collagen capsulation is found surrounding the PSer hydrogels after 4 weeks, 3 months and 7 months post implantation. Histological analysis on inflammatory cytokines and RNA-seq assay both indicate that PSer hydrogels show low FBR, comparable to the Mock group. The anti-FBR performance of PSer hydrogels at all time points surpass the poly(ethyleneglycol) hydrogels that is widely utilized as bio-inert materials, implying the potent and wide application of PSer materials in implantable biomaterials and biomedical devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.