ArticleProceedings of the National Academy of Sciences of the United States of America2021
Blood pressure, executive function, and network connectivity in middle-aged adults at risk of dementia in late life.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Cumulative blood pressure and risk of dementia and cognitive decline: a systematic review and meta-analysis.The journal of prevention of Alzheimer's disease · 2026Pooled it
- Additional Effects of 1-Hz rTMS Combined With Tai Chi Chuan on Dual-Task Performance Among Older Adults With Sleep Disorders and MCI: An fNIRS-Based Randomized Controlled Trial.Brain and behavior · 2026Trial
- Peripheral inflammation impairs glymphatic function, contributing to neurodegeneration in Alzheimer's disease.iScience · 2026Article
- Functional Connectome Predicts Cognition and Links White Matter Hyperintensity Burden to Cognitive Impairment Across the Vascular Cognitive Impairment Continuum.Brain sciences · 2026Article
- Age-related and dual task-induced gait alterations and asymmetry: optimizing the Semmelweis Study gait assessment protocol.GeroScience · 2025Article
- Beyond Focal Lesions: Dynamical Network Effects of White Matter Hyperintensities.Human brain mapping · 2024Article
- Article
- White Matter Hyperintensities and Mild TBI in Post-9/11 Veterans and Service Members.Military medicine · 2024Article
- Long-term blood pressure patterns in midlife and dementia in later life: Findings from the Framingham Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- A functional connectome signature of blood pressure in >30 000 participants from the UK biobank.Cardiovascular research · 2023Article
- Review
- Brain Structural and Functional Changes in Cognitive Impairment Due to Alzheimer's Disease.Frontiers in psychology · 2022Review
- The Brain Health Platform: Combining Resilience, Vulnerability, and Performance to Assess Brain Health and Risk of Alzheimer's Disease and Related Disorders.Journal of Alzheimer's disease : JAD · 2022Article
- White matter hyperintensities mediate a greater proportion of age-related lower cognitive scores in non-Hispanic White participants compared to non-Hispanic Black and Hispanic participants: HABS-HD.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
Midlife blood pressure is associated with structural brain changes, cognitive decline, and dementia in late life. However, the relationship between early adulthood blood pressure exposure, brain structure and function, and cognitive performance in midlife is not known. A better understanding of these relationships in the preclinical stage may advance our mechanistic understanding of vascular contributions to late-life cognitive decline and dementia and may provide early therapeutic targets. To identify resting-state functional connectivity of executive control networks (ECNs), a group independent components analysis was performed of functional MRI scans of 600 individuals from the Coronary Artery Risk Development in Young Adults longitudinal cohort study, with cumulative systolic blood pressure (cSBP) measured at nine visits over the preceding 30 y. Dual regression analysis investigated performance-related connectivity of ECNs in 578 individuals (mean age 55.5 ± 3.6 y, 323 female, 243 Black) with data from the Stroop color-word task of executive function. Greater connectivity of a left ECN to the bilateral anterior gyrus rectus, right posterior orbitofrontal cortex, and nucleus accumbens was associated with better executive control performance on the Stroop. Mediation analyses showed that while the relationship between cSBP and Stroop performance was mediated by white matter hyperintensities (WMH), resting-state connectivity of the ECN mediated the relationship between WMH and executive function. Increased connectivity of the left ECN to regions involved in reward processing appears to compensate for the deleterious effects of WMH on executive function in individuals across the burden of cumulative systolic blood pressure exposure in midlife.
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