ArticleJournal of clinical pathology2021
Comparative clinicopathological and immunohistochemical study of micronodular thymoma and micronodular thymic carcinoma with lymphoid stroma.
Article in Journal of clinical pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Micronodular thymic epithelial tumors with lymphoid hyperplasia and mimicking lesions.Histology and histopathology · 2025Review
- Factors distinguishing thymomas from thymic squamous cell carcinoma: a proposal for diagnosis emphasizing the immunophenotype.Mediastinum (Hong Kong, China) · 2025Review
- Surgical resection of micronodular thymic carcinoma with lymphoid hyperplasia: a case report.General thoracic and cardiovascular surgery cases · 2023Article
- The clinicopathological significance of thymic epithelial markers expression in thymoma and thymic carcinoma.BMC cancer · 2023Article
- Experimental model of micronodular thymic neoplasm with lymphoid stroma.Thoracic cancer · 2023Article
- Micronodular thymoma with lymphoid stroma: Contrast-enhanced CT features with histopathological correlation in 10 patients.Frontiers in oncology · 2022Article
- Histological Classification and Invasion Prediction of Thymoma by Machine Learning-Based Computed Tomography Imaging.Contrast media & molecular imaging · 2022Article
- Thymolipoma - the frontier between hamartoma and neoplasia?Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
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Authors and funding
6 authors.
Funding
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Abstract
aimTo elucidate the clinicopathological and immunohistochemical characteristics of micronodular thymomas (MNTs) and micronodular thymic carcinomas (MNCs) with lymphoid stroma.
methodsWe examined four cases of MNTs and three cases of MNCs pathologically and immunohistochemically.
resultsThere were prominent cystic changes infive of the seven cases. The neoplasms contained epithelial tumour cells arranged in a micronodular growth pattern lined by cystic walls and separated by abundant lymphoid stroma. Only the tumour cell component of MNCs showed signs of malignancy characterised by cytological atypia and increased mitotic activity. Neoplastic MNC epithelial cells showed strong positivity for CD5 and CD117. However, no immature lymphocytes (TdT-positive and CD99-positive) were present in and around the tumour nodules. None of the patients died or suffered from disease due to MNTs or MNCs.
conclusionMNTs and MNCs are rare and less aggressive forms of thymic tumours and can be differentially diagnosed by immunohistochemistry.
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