Evidence map›Paper›PMID 34493590›Full record

ReviewMolecular cancer therapeutics2021

Hallmarks of RET and Co-occuring Genomic Alterations in

Jacob J Adashek, Aakash P Desai, Alexander Y Andreev-Drakhlin, Jason Roszik, Gilbert J Cote, Vivek Subbiah

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular cancer therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Characterization ofTranslational lung cancer research · 2025
    Article
  3. Tumour-agnostic kinase inhibitors.Nature reviews. Drug discovery · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. The Role of Zuo Jin Wan in Modulating the Tumor Microenvironment of Colorectal Cancer.Combinatorial chemistry & high throughput screening · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jacob J AdashekDepartment of Internal Medicine, University of South Florida, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.ORCID 0000-0003-4272-312X
Aakash P DesaiDivision of Medical Oncology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-2943-3817
Alexander Y Andreev-DrakhlinDepartment of Investigational Cancer Therapeutics, Division of Cancer Medicine, Houston, Texas.
Jason RoszikDepartment of Investigational Cancer Therapeutics, Division of Cancer Medicine, Houston, Texas.ORCID 0000-0002-4561-6170
Gilbert J CoteDepartment of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Vivek SubbiahDepartment of Investigational Cancer Therapeutics, Division of Cancer Medicine, Houston, Texas. vsubbiah@mdanderson.org.ORCID 0000-0002-6064-6837
The University of Texas MD Anderson Cancer Center · USMayo Clinic · USMoffitt Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Convalescent Plasma to Limit Coronavirus Associated ComplicationsUL1TR003167 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARP, DANIEL D, MCPHERSON, DAVID D · 2019 to 2023
$45.3M
Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
TRAINING FOR ACADEMIC ONCOLOGY/HEMATOLOGYT32CA009666 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Michael Davies, Courtney DiNardo · 1994 to 2026
$9.8M
Blocking tumor progression in therapy-responsive RET aberration-associated cancerR01CA242845 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI AHNERT, JORDI RODON, MOOERS, BLAINE H. M. · 2020 to 2024
$1.9M
Informatics to enable routine personalized cancer therapyU01CA180964 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BERNSTAM, ELMER V., MERIC-BERNSTAM, FUNDA · 2013 to 2015
$964k
NCATS NIH HHS UL1 TR000371NCATS NIH HHS UL1 TR003167NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA242845NCI NIH HHS T32 CA009666NCI NIH HHS U01 CA180964
6 · The paper itself

Abstract

Activating receptor-tyrosine kinase rearranged during transfection

Indexed as

MutationAnimalsHumansNeoplasmsOncogene Proteins, FusionProtein Kinase InhibitorsProto-Oncogene Proteins c-retOncogene Proteins, FusionProtein Kinase InhibitorsProto-Oncogene Proteins c-ret

Identifiers

PMID34493590
PMCPMC8492504
OpenAlexW3197377580

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.