ArticleBMJ case reports2021
Reactivation of herpes simplex keratitis following vaccination for COVID-19.
Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- A Systematic Review of Ocular Complications Following Different Types of Covid-19 Vaccines.Journal of immunology research · 2025Pooled it
- Case Series: Reactivation of Herpetic Keratitis After COVID-19 mRNA Vaccination During Herpetic Prophylaxis.Vision (Basel, Switzerland) · 2025Article
- The WHO Algorithm for Causality Assessment of Adverse Effects Following Immunization with Genetic-Based Anti-COVID-19 Vaccines: Pitfalls and Suggestions for Improvement.Journal of clinical medicine · 2024Article
- Herpes simplex keratitis: A brief clinical overview.World journal of virology · 2024Review
- Corneal Adverse Events Associated with SARS-CoV-2/COVID-19 Vaccination: A Systematic Review.Vaccines · 2023Review
- Analysis of clinical characteristics and factors influencing herpes simplex virus keratitis.Frontiers in medicine · 2023Article
- Corneal Complications after COVID-19 Vaccination: A Systemic Review.Journal of clinical medicine · 2022Review
- Review
- SARS-CoV-2 infection and lytic reactivation of herpesviruses: A potential threat in the postpandemic era?Journal of medical virology · 2022Review
- Herpetic endotheliitis and stromal keratitis following inactivated COVID-19 vaccination.Clinical case reports · 2022Article
- COVID-19 Vaccination and The Eye.American journal of ophthalmology · 2022Review
- Reactivation of Herpes Simplex Keratitis on a Corneal Graft Following SARS-CoV-2 mRNA Vaccination.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2022Article
- Herpetic anterior uveitis following Pfizer-BioNTech coronavirus disease 2019 vaccine: two case reports.Journal of medical case reports · 2022Article
- Relapsed Disciform Stromal Herpetic Keratitis Following mRNA COVID-19 Vaccination: A Case Report.Korean journal of ophthalmology : KJO · 2022Article
- Commentary: Case report: Associated ocular adverse reactions with inactivated COVID-19 vaccine in China.Frontiers in medicine · 2022Article
- Acute Unilateral Peripheral Vestibulopathy After COVID-19 Vaccination: Initial Experience in a Tertiary Neurotology Center.Frontiers in neurology · 2022Article
- Herpetic Keratitis Preceded by COVID-19 Vaccination.Vaccines · 2021Article
- Case Report: Associated Ocular Adverse Reactions With Inactivated COVID-19 Vaccine in China.Frontiers in medicine · 2021Article
- Unilateral Acute Central Serous Chorioretinopathy with Inactivated Coronavirus Disease 2019 Vaccination: A Case Report and Review of Literature.Journal of current ophthalmologyArticle
- Presumably Corneal Graft Rejection after COVID-19 Vaccination.Case reports in ophthalmologyArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An 82-year-old man with a history of herpes simplex keratitis 40 years previously presented with recurrence, 1 day following vaccination for novel COVID-19. His condition worsened despite topical treatment with ganciclovir gel. A diagnosis of herpetic stromal keratitis was made, requiring systemic aciclovir, topical prednisolone, moxifloxacin and atropine, and oral doxycycline. He improved clinically on treatment, with some residual corneal scarring. Visual acuity improved from 6/36 corrected at presentation, to 6/24 following treatment. Clearly, public and personal health benefits from vaccination are hugely important and we would not suggest avoiding vaccination in such patients. It is, however, important for ophthalmic providers to be aware of the rare potential for reactivation of herpetic eye disease following vaccination to enable prompt diagnosis and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.