ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Reliable Sensory Processing in Mouse Visual Cortex through Cooperative Interactions between Somatostatin and Parvalbumin Interneurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- DeepFaceMouse enables scalable prediction of large-scale brain activity from facial dynamics in mice.Cell reports methods · 2026Article
- Functional organization of dendritic spines in mouse visual cortex layer 2/3 neurons.iScience · 2026Article
- Dorsal prefrontal cortex drives perseverative behavior in mice.Nature communications · 2026Article
- Feature-tuned synaptic inputs to somatostatin interneurons drive context-dependent processing.Neuron · 2026Article
- Selective filtering of relevant sensory signals in parietal cortex.Research square · 2026Article
- Developmental and early-life stress-induced effects on 5-HTNeurobiology of stress · 2026Article
- Developmental and Early-Life Stress-Induced Effects on 5-HTbioRxiv : the preprint server for biology · 2025Article
- Temporal coding carries more stable cortical visual representations than firing rate over time.Nature communications · 2025Article
- State modulation in spatial networks with three interneuron subtypes.Science advances · 2025Article
- Spike reliability is cell type specific and shapes excitation and inhibition in the cortex.Scientific reports · 2025Article
- Marmoset superior colliculus: neuronal expression of somatostatin but not vasoactive intestinal peptide or neuropeptide Y.Frontiers in neuroanatomy · 2025Article
- Local stimulation of pyramidal neurons in deep cortical layers of anesthetized rats enhances cortical visual information processing.Scientific reports · 2024Article
- Simultaneous interneuron labeling reveals cell type-specific, population-level interactions in cortex.iScience · 2024Article
- Article
- Simultaneous interneuron labeling reveals population-level interactions among parvalbumin, somatostatin, and pyramidal neurons in cortex.bioRxiv : the preprint server for biology · 2024Article
- Arousal and Locomotion Differently Modulate Activity of Somatostatin Neurons across Cortex.eNeuro · 2023Article
- Single spikes drive sequential propagation and routing of activity in a cortical network.eLife · 2023Article
- Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Review
- Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits.Nature communications · 2022Article
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Authors and funding
5 authors.
Funding
Abstract
Intrinsic neuronal variability significantly limits information encoding in the primary visual cortex (V1). However, under certain conditions, neurons can respond reliably with highly precise responses to the same visual stimuli from trial to trial. This suggests that there exists intrinsic neural circuit mechanisms that dynamically modulate the intertrial variability of visual cortical neurons. Here, we sought to elucidate the role of different inhibitory interneurons (INs) in reliable coding in mouse V1. To study the interactions between somatostatin-expressing interneurons (SST-INs) and parvalbumin-expressing interneurons (PV-INs), we used a dual-color calcium imaging technique that allowed us to simultaneously monitor these two neural ensembles while awake mice, of both sexes, passively viewed natural movies. SST neurons were more active during epochs of reliable pyramidal neuron firing, whereas PV neurons were more active during epochs of unreliable firing. SST neuron activity lagged that of PV neurons, consistent with a feedback inhibitory SST→PV circuit. To dissect the role of this circuit in pyramidal neuron activity, we used temporally limited optogenetic activation and inactivation of SST and PV interneurons during periods of reliable and unreliable pyramidal cell firing. Transient firing of SST neurons increased pyramidal neuron reliability by actively suppressing PV neurons, a proposal that was supported by a rate-based model of V1 neurons. These results identify a cooperative functional role for the SST→PV circuit in modulating the reliability of pyramidal neuron activity.
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