Evidence map›Paper›PMID 34493542›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Critical Role of Astrocyte NAD

Monica R Langley, Chan-Il Choi, Thais R Peclat, Yong Guo, Whitney L Simon, Hyesook Yoon, Laurel Kleppe, Claudia F Lucchinetti, Claudia C S Chini, Eduardo N Chini and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. REV-ERBα regulates brain NADNature aging · 2025
    Article
  3. CD38 connects the heart and brain.Translational psychiatry · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Targeting NAD+ Metabolism to Modulate Autoimmunity and Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Review
  10. Astrocytic TIMP-1 regulates production of Anastellin, an inhibitor of oligodendrocyte differentiation and FTY720 responses.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Review
  12. Nicotinamide Adenine Dinucleotide (NADAntioxidants & redox signaling · 2023
    Review
  13. Review
  14. ATP and NADNutrients · 2023
    Article
  15. Article
  16. NADProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Monica R LangleyDepartment of Physical Medicine and Rehabilitation, Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, Minnesota 55905.
Chan-Il ChoiDepartment of Physical Medicine and Rehabilitation, Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, Minnesota 55905.
Thais R PeclatRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota 55905.
Yong GuoDepartment of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905.
Whitney L SimonDepartment of Physical Medicine and Rehabilitation, Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, Minnesota 55905.
Hyesook YoonDepartment of Physical Medicine and Rehabilitation, Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, Minnesota 55905.
Laurel KleppeDepartment of Physical Medicine and Rehabilitation, Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, Minnesota 55905.
Claudia F LucchinettiDepartment of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905.
Claudia C S ChiniRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota 55905.
Eduardo N ChiniRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota 55905.
Isobel A ScarisbrickDepartment of Physical Medicine and Rehabilitation, Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, Minnesota 55905 scarisbrick.isobel@mayo.edu.ORCID 0000-0003-2395-589X
Mayo Clinic · USMayo Clinic in Florida · US

Funding

Role of Protease Activated Receptors in Spinal Cord Injury and RepairR01NS052741 · NINDS · MAYO CLINIC ROCHESTER · PI SCARISBRICK, ISOBEL A · 2008 to 2017
$3.6M
Therapeutic implication of CD38 in CLLR01CA233790 · NCI · MAYO CLINIC JACKSONVILLE · PI CHINI, EDUARDO N · 2019 to 2023
$3.0M
Role of CD38 in NAD metabolism: from the basic biology of aging to translationR01AG058812 · NIA · MAYO CLINIC ROCHESTER · PI CHINI, EDUARDO N · 2018 to 2022
$2.0M
NCI NIH HHS R01 CA233790NIA NIH HHS R01 AG058812NINDS NIH HHS R01 NS052741
6 · The paper itself

Abstract

Western-style diets cause disruptions in myelinating cells and astrocytes within the mouse CNS. Increased CD38 expression is present in the cuprizone and experimental autoimmune encephalomyelitis models of demyelination and CD38 is the main nicotinamide adenine dinucleotide (NAD

Indexed as

ADP-ribosyl Cyclase 1AnimalsAstrocytesCerebellumDiet, High-FatMaleMembrane GlycoproteinsMiceMice, Inbred C57BLMice, TransgenicMyelin SheathNAD+ NucleosidaseNerve RegenerationOrgan Culture TechniquesRemyelinationADP-ribosyl Cyclase 1Cd38 protein, mouseMembrane GlycoproteinsNAD+ NucleosidaseastrocyteCD38 multiple sclerosismyelinNAD+oligodendrocyte

Identifiers

PMID34493542
PMCPMC8513702
OpenAlexW3197958744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.