Evidence map›Paper›PMID 34493403›Full record

ArticleTrends in genetics : TIG2022

Heritable epigenetic changes at single genes: challenges and opportunities in Caenorhabditis elegans.

Mary Chey, Antony M Jose

Open access · greenAbstract read
In one paragraph

Article in Trends in genetics : TIG, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Grandfathers-to-Grandsons Transgenerational Transmission of Exercise Positive Effects on Cognitive Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  3. Article
  4. Article
  5. Evidence for multiple forms of heritable RNA silencing.bioRxiv : the preprint server for biology · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mary CheyDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
Antony M JoseDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA. Electronic address: amjose@umd.edu.
University of Maryland, College Park · US

Funding

Transgenerational gene silencing by extracellular RNAR01GM124356 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI JOSE, ANTONY MERLIN · 2018 to 2025
$2.8M
NIGMS NIH HHS R01 GM124356
6 · The paper itself

Abstract

Organisms rely on stereotyped patterns of gene expression for similar form and function in every generation. The analysis of epigenetic changes in the expression of different genes across generations can provide the rationale for measured actions in one generation that consider impact on future generations.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsAnimalsEpigenesis, GeneticInheritance PatternsCaenorhabditis elegans Proteinsregulatory networksRNAitransgenerational epigenetic inheritance (TEI)

Identifiers

PMID34493403
PMCPMC9436772
OpenAlexW3197096357

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.