Evidence map›Paper›PMID 34493300›Full record

ArticleJournal of translational medicine2021

Evaluating predictive factors for toxicities experienced by head & neck cancer patients undergoing radiotherapy.

Xenia Ray, Whitney Sumner, Leisa Sutton, Parag Sanghvi, Ida Deichaite, Vitali Moiseenko

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xenia RayDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Whitney SumnerDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Leisa SuttonMoores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Parag SanghviDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Ida DeichaiteDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA. ideichaite@ucsd.edu.ORCID 0000-0001-8839-0573
Vitali MoiseenkoDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
University of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study was to evaluate if HPV status serves as an independent predictor of early and late dysphagia outcomes when considered alongside standard patient characteristics and dose metrics for head and neck cancer patients treated with radiotherapy. METHODS AND MATERIALS: The age, sex, smoking history, cancer type (oropharyngeal vs non-oropharyngeal), HPV status, and early and late dysphagia outcomes were obtained for 99 retrospective head and neck cancer patients treated at our clinic with radiotherapy. Additionally for each patient, the mean radiation dose to the pharynx, superior/middle/inferior pharyngeal constrictor muscles, and cricopharyngeus was calculated. The predictive power of these clinical characteristics and radiation metrics was evaluated using chi-square tests for categorical variables and t-tests for continuous variables. Then multi-variate logistic models were built for each outcome using a single dose metric at a time, and either HPV status, cancer type, or both. Multi-variate models were built using both top-down and bottom-up technique to establish the most predictive independent covariates.

resultsIn the univariate analysis for early dysphagia, cancer type (p = 0.04) and four dose metrics (p ≤ 0.02) were significantly associated with outcome, while for late dysphagia, only cancer type (p = 0.04) was associated with outcome. In the multivariate analysis for early dysphagia, cancer type, smoking history, and mean dose to the five structures were consistently selected as covariates. For late dysphagia, either HPV status or cancer type was selected in each model and the mean dose to the cricopharyngeus was selected in one model.

conclusionWhile HPV is a known contributing factor for tumor prognosis in oropharyngeal cancers, its role in normal tissue toxicities for head and neck cancers has not previously been evaluated. Our results indicate having an oropharyngeal cancer may increase a patient's risk of high-grade early and late dysphagia while HPV status was seldom selected.

Indexed as

Deglutition DisordersHead and Neck NeoplasmsOropharyngeal NeoplasmsHumansPharyngeal MusclesRetrospective StudiesHead and neck squamous cell carcinomaHuman papilloma virusPredictive biomarkers of radiation toxicityRT dosimetric data

Identifiers

PMID34493300
PMCPMC8425061
OpenAlexW3198104784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.