ArticleGenome biology2021
SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits.
Article in Genome biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 8 of them syntheses that pooled it.
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Who cites it
131 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Multi-Trait Genetic Insights Into Schizophrenia Across Ancestries: Genome-Wide Association Meta-Analyses, Machine Learning, and Drug Repurposing Study.Brain and behavior · 2026Pooled it
- Genetic overlap and causality between depression and preterm birth: a large-scale genome-wide cross-trait analysis.Psychological medicine · 2025Pooled it
- Multi-ancestry meta-analysis of genome-wide association studies discovers 67 new loci associated with chronic back pain.Nature communications · 2025Pooled it
- Identification ofDepression and anxiety · 2025Pooled it
- Epidemiological and Genetic Analyses of Schizophrenia and Breast Cancer.Schizophrenia bulletin · 2024Pooled it
- Advancing crop improvement through GWAS and beyond in mung bean.Frontiers in plant science · 2024Pooled it
- Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses.BMC medicine · 2023Pooled it
- Migraine, chronic kidney disease and kidney function: observational and genetic analyses.Human genetics · 2023Pooled it
- Deciphering the interplay between serum urate and bone mineral density: insights from observational and genetic perspectives.Journal of the International Society of Sports Nutrition · 2026Article
- Shared genetics of IgA nephropathy and cardiometabolic diseases revealed by integrative genomic analysis.Renal failure · 2026Article
- Exploring the shared genetic architecture between post-traumatic stress disorder (PTSD) and obstructive sleep apnea (OSA).European journal of psychotraumatology · 2026Article
- Genetic interconnections between personality-related phenotypes and psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2026Article
- Identifying shared polygenic risk across cancers.PLoS genetics · 2026Article
- Large-scale pleiotropic analysis across cancers reveals shared genetic mechanisms and identifies novel functional genes.Briefings in bioinformatics · 2026Article
- Estimating genetic correlation jointly using individual-level and summary-level GWAS data.Nature communications · 2026Article
- Cross-trait genetic analysis maps shared polygenic architecture between primary aldosteronism and blood pressure to adrenal cell states.Journal of translational medicine · 2026Article
- FCGR2A promoter variant reveals shared genetic susceptibility between IBD and stroke.Molecular and cellular biochemistry · 2026Article
- Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- pGWAS-Portal: a comprehensive online platform for integrative post-genome-wide association study analysis.BMC genomics · 2026Article
- The genetic architecture of cortical similarity networks.Nature communications · 2026Article
71 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors.
Funding
Abstract
Local genetic correlation quantifies the genetic similarity of complex traits in specific genomic regions. However, accurate estimation of local genetic correlation remains challenging, due to linkage disequilibrium in local genomic regions and sample overlap across studies. We introduce SUPERGNOVA, a statistical framework to estimate local genetic correlations using summary statistics from genome-wide association studies. We demonstrate that SUPERGNOVA outperforms existing methods through simulations and analyses of 30 complex traits. In particular, we show that the positive yet paradoxical genetic correlation between autism spectrum disorder and cognitive performance could be explained by two etiologically distinct genetic signatures with bidirectional local genetic correlations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.