ArticleBMC biology2021
Large-scale genomic analysis of antimicrobial resistance in the zoonotic pathogen Streptococcus suis.
Article in BMC biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 87 citations in OpenAlex.
- Whole Genome Characterization of Klebsiella Strains in European Hedgehogs and Human Nosocomial Settings Identified Shared Sequence Types, Antimicrobial Resistance Genes and Plasmids.Zoonoses and public health · 2026Article
- Species Identification and Antimicrobial Resistance ofAnimals : an open access journal from MDPI · 2026Article
- Streptococcus suis in Asia: epidemiology, transmission and zoonotic risk at the animal-human interface.Veterinary research communications · 2026Review
- Non-penicillin -susceptible and linezolid-non-susceptible Streptococcus suis clonal complex 233 from humans.Scientific reports · 2026Article
- Streptococcus suis avian expansion suggests shared antibiotic use drives host jumps.BMC biology · 2025Article
- Review
- Diversity and antimicrobial resistance among bacterial isolates from finfish aquaculture in Thailand.BMC veterinary research · 2025Article
- Pan-immune system, mobilome and resistome inMicrobial genomics · 2025Article
- Nasal Colonizers from Sows in the Federal District of Brazil Showed a Diverse Phenotypic Resistance Profile.Microorganisms · 2025Article
- Characterization of antibiotic determinants and heavy metal resistance genes inMicrobial genomics · 2025Article
- Sharing ofmBio · 2025Article
- Genomic insights into bacteriophages: a new frontier in AMR detection and phage therapy.Briefings in functional genomics · 2025Review
- Isolation of phages infecting the zoonotic pathogenbioRxiv : the preprint server for biology · 2025Article
- Article
- Article
- Molecular characterization of Streptococcus suis isolates recovered from diseased pigs in Europe.Veterinary research · 2024Article
- Virulence genes, resistome and mobilome ofMicrobial genomics · 2024Article
- Streptococcus suis serotype 9 in Italy: genomic insights into high-risk clones with emerging resistance to penicillin.The Journal of antimicrobial chemotherapy · 2024Article
- First WGS Characterization ofTransboundary and emerging diseases · 2024Article
- The emergence and diversification of a zoonotic pathogen from within the microbiota of intensively farmed pigs.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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Authors and funding
17 authors at 7 institutions in 6 countries.
Funding
Abstract
backgroundAntimicrobial resistance (AMR) is among the gravest threats to human health and food security worldwide. The use of antimicrobials in livestock production can lead to emergence of AMR, which can have direct effects on humans through spread of zoonotic disease. Pigs pose a particular risk as they are a source of zoonotic diseases and receive more antimicrobials than most other livestock. Here we use a large-scale genomic approach to characterise AMR in Streptococcus suis, a commensal found in most pigs, but which can also cause serious disease in both pigs and humans.
resultsWe obtained replicated measures of Minimum Inhibitory Concentration (MIC) for 16 antibiotics, across a panel of 678 isolates, from the major pig-producing regions of the world. For several drugs, there was no natural separation into 'resistant' and 'susceptible', highlighting the need to treat MIC as a quantitative trait. We found differences in MICs between countries, consistent with their patterns of antimicrobial usage. AMR levels were high even for drugs not used to treat S. suis, with many multidrug-resistant isolates. Similar levels of resistance were found in pigs and humans from regions associated with zoonotic transmission. We next used whole genome sequences for each isolate to identify 43 candidate resistance determinants, 22 of which were novel in S. suis. The presence of these determinants explained most of the variation in MIC. But there were also interesting complications, including epistatic interactions, where known resistance alleles had no effect in some genetic backgrounds. Beta-lactam resistance involved many core genome variants of small effect, appearing in a characteristic order.
conclusionsWe present a large dataset allowing the analysis of the multiple contributing factors to AMR in S. suis. The high levels of AMR in S. suis that we observe are reflected by antibiotic usage patterns but our results confirm the potential for genomic data to aid in the fight against AMR.
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