ArticleBMC cardiovascular disorders2021
Accuracy of neutrophil to lymphocyte and monocyte to lymphocyte ratios as new inflammatory markers in acute coronary syndrome.
Article in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Neutrophil to lymphocyte ratio in odontogenic infection: a systematic review.Head & face medicine · 2024Pooled it
- Prognostic impact of monocyte-to-lymphocyte ratio in coronary heart disease: a systematic review and meta-analysis.The Journal of international medical research · 2023Pooled it
- Diagnostic Performance of Complete Blood Count Derived Indices for Acute Coronary Syndrome in Emergency Department Patients With Acute Chest Pain: A Single-Center Retrospective Diagnostic Accuracy Study.Health science reports · 2026Article
- CBC-Derived Inflammatory Indices and Myocardial Injury Severity at Presentation in Acute Myocardial Infarction: Association and Discriminative Performance.Journal of clinical medicine · 2026Article
- Early Identification of ST-Segment Elevation Myocardial Infarction (STEMI) at Presentation: Comparative Diagnostic Performance of CBC-Derived Inflammatory Indices and High-Sensitivity Troponin T.Journal of clinical medicine · 2026Article
- Postoperative Day-28 Neutrophil-to-Lymphocyte Ratio as a Predictor of Early Mortality After Lung Transplantation.Diagnostics (Basel, Switzerland) · 2026Article
- A composite model incorporating systemic inflammatory burden and GRACE score for enhanced identification of elevated myocardial stress in acute myocardial infarction: an exploratory analysis.Frontiers in cardiovascular medicine · 2026Article
- The relationship between in-hospital mortality and Naples prognostic score in patients undergoing tricuspid valve surgery.Revista da Associacao Medica Brasileira (1992) · 2026Article
- DeRitis ratio is associated with unfavorable prognosis in ACS patients.Frontiers in cardiovascular medicine · 2026Article
- A study on the correlation between novel inflammatory indices and severity of coronary artery lesions in patients with stable coronary artery disease.Frontiers in cardiovascular medicine · 2026Article
- Comparison of inflammatory cells, C-reactive protein, and lipid profile in atherosclerotic cardiovascular disease patients and healthy controls in Northwest Ethiopia.Scientific reports · 2025Article
- The Monocyte-to-Lymphocyte Ratio Exhibits A Superior Prognostic Value in Patients with Newly Diagnosed Acute Coronary Syndrome.Reviews in cardiovascular medicine · 2025Article
- A novel indicator of all-cause mortality in acute coronary syndrome: the CALLY index.Biomarkers in medicine · 2025Article
- Study of Monocyte-High Density Lipoprotein ratio to coronary artery diameter in coronary heart disease patients.Global cardiology science & practice · 2025Article
- Sex differences of neutrophil to high-density lipoprotein cholesterol ratio in predicting the severity of coronary lesions in acute coronary syndrome patients.Lipids in health and disease · 2025Article
- The Relationship Between Advanced Lung Cancer Inflammation Index and Adverse Clinical Outcomes in Patients with Myocardial Infarction with No-Obstructive Coronary Arteries.Journal of inflammation research · 2025Article
- Analysis of the correlation between the Systemic Inflammatory Response Index and the severity of coronary vasculopathy.Biomolecules & biomedicine · 2024Article
- Inflammatory and Lipid Biomarkers in Early Atherosclerosis: A Comprehensive Analysis.Life (Basel, Switzerland) · 2024Article
- Advanced Lung Cancer Inflammation Index as Predictor of All-Cause Mortality in ST-Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention.Journal of clinical medicine · 2024Article
- Association between Inflammatory Burden Index and cardiovascular disease in adult Americans: Evidence from NHANES 2005-2010.Heliyon · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammation plays a key role in the development of atherosclerosis and in the pathogenesis of acute coronary syndrome (ACS). Leukocytes and leukocytes ratios were recognized as inflammatory markers in predicting the presence and severity of ACS.
methodsThis study aimed to investigate the diagnostic accuracy of neutrophil to lymphocyte ratio (NLR) and monocyte to lymphocyte ratio (MLR) with ACS. One hundred patients admitted to the Cardiac Center who were confirmed to have ACS and 100 healthy controls confirmed not to have ACS were enrolled in this study. ECG and troponin I test were used as gold standards to make sure that the participants with or without ACS. Total white blood cells (WBCs) count, NLR, and MLR values were estimated.
resultsTotal WBCs, neutrophil, and monocyte counts were significantly higher while lymphocyte counts were significantly lower in ACS patients than in the healthy controls (p < 0.001). NLR and MLR were significantly higher in ACS patients than in the healthy controls (p < 0.001). Among all the studied markers, NLR was found to be the strongest predictive marker of ACS (OR: 3.3, p < 0.001), whereas MLR was non-significant (p > 0.05). A cut-off value of 2.9 of NLR had 90% sensitivity and 88% specificity while 0.375 cut-off value of MLR had 79% sensitivity, 91% specificity for predicting ACS presence.
conclusionsNLR is a simple, widely available, and inexpensive inflammatory marker which can be an auxiliary biomarker in the diagnosis of ACS with a cut-off value of 2.9 in our population.
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