Evidence map›Paper›PMID 34493094›Full record

ArticleJournal of the Royal Society, Interface2021

Inferring simple but precise quantitative models of human oocyte and early embryo development.

Brian D Leahy, Catherine Racowsky, Daniel Needleman

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06179420 (The Effectiveness of Advanced Decision Support Tool), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06179420 unknown statusnot on this mapstarted 2024, after this paper: background citation

The Effectiveness of Advanced Decision Support Tool (OPT-IVF) for IVF Treatment

TypeobservationalSponsorNational University of MalaysiaRan2024 to 2026Enrolled30ConditionsFertility IssuesArmstotal cumulative gonadotrophin usage
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Brian D LeahyDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-0070-0985
Catherine RacowskyBrigham Women's Hospital, Boston, MA, USA.
Daniel NeedlemanDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.
Harvard University · USBrigham and Women's Hospital · US

Funding

Enhancing Assisted Reproductive Technologies with Deep Learning and Data VisualizationR01HD104969 · NICHD · HARVARD UNIVERSITY · PI BEN YOSEF, DALIT, NEEDLEMAN, DANIEL · 2021 to 2025
$3.4M
Causes and consequences of mitochondrial dysfunction in oocytes and cumulus cellsR01HD092550 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI GINSBURG, ELIZABETH S, RACOWSKY, CATHERINE · 2017 to 2021
$2.6M
NICHD NIH HHS R01 HD092550NICHD NIH HHS R01 HD104969
6 · The paper itself

Abstract

Macroscopic, phenomenological models are useful as concise framings of our understandings in fields from statistical physics to finance to biology. Constructing a phenomenological model for development would provide a framework for understanding the complicated, regulatory nature of oogenesis and embryogenesis. Here, we use a data-driven approach to infer quantitative, precise models of human oocyte maturation and pre-implantation embryo development, by analysing clinical

Indexed as

Embryonic DevelopmentOocytesFemaleFertilization in VitroHumansOogenesisOvarian Folliclehuman embryosin-vitro fertilizationpre-implantation developmentquantitative biology

Identifiers

PMID34493094
PMCPMC8424348
OpenAlexW3137468082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.