Evidence map›Paper›PMID 34493070›Full record

ArticleOpen biology2021

CG7379 and ING1 suppress cancer cell invasion by maintaining cell-cell junction integrity.

Alexandra D Rusu, Zoe E Cornhill, Brenda Canales Coutiño, Marcos Castellanos Uribe, Anbarasu Lourdusamy, Zsuzsa Markus, Sean T May, Ruman Rahman, Marios Georgiou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Alexandra D RusuSchool of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.ORCID 0000-0001-6362-015X
Zoe E CornhillSchool of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.
Brenda Canales CoutiñoSchool of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.
Marcos Castellanos UribeSchool of Biosciences, University of Nottingham, Sutton Bonington, Leicestershire LE12 5RD, UK.
Anbarasu LourdusamySchool of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK.
Zsuzsa MarkusSchool of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.ORCID 0000-0001-7045-4436
Sean T MaySchool of Biosciences, University of Nottingham, Sutton Bonington, Leicestershire LE12 5RD, UK.ORCID 0000-0001-5282-3250
Ruman RahmanSchool of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK.
Marios GeorgiouSchool of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.ORCID 0000-0003-3321-9124
University of Nottingham · GB

Funding

Biotechnology and Biological Sciences Research Council BB/E022758/1Biotechnology and Biological Sciences Research Council BB/I001271/1Cancer Research UK 12891National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/S001417/1
6 · The paper itself

Abstract

Approximately 90% of cancer-related deaths can be attributed to a tumour's ability to spread. We have identified CG7379, the fly orthologue of human ING1, as a potent invasion suppressor. ING1 is a type II tumour suppressor with well-established roles in the transcriptional regulation of genes that control cell proliferation, response to DNA damage, oncogene-induced senescence and apoptosis. Recent work suggests a possible role for ING1 in cancer cell invasion and metastasis, but the molecular mechanism underlying this observation is lacking. Our results show that reduced expression of CG7379 promotes invasion

Indexed as

Cell CommunicationGene Expression Regulation, NeoplasticAnimalsApoptosisBreast NeoplasmsCell ProliferationDrosophila melanogasterDrosophila ProteinsFemaleHumansInhibitor of Growth Protein 1MCF-7 CellsNeoplasm InvasivenessTranscriptomeDrosophila ProteinsInhibitor of Growth Protein 1cancercell–cell junctionsDrosophila melanogasterING1invasiontumour suppressor

Identifiers

PMID34493070
PMCPMC8424350
OpenAlexW3196479208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.