ArticleBrain and behavior2021
Cognitive impairment and all-cause mortality among Chinese adults aged 80 years or older.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Amplitude of low-frequency fluctuation (ALFF) alterations in heart transplant patients with cognitive impairment: a resting-state fMRI study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Role of cognitive impairment in predicting the long-term risk of all-cause mortality: a 20-year prospective cohort study in China.Archives of public health = Archives belges de sante publique · 2025Article
- VR Cognitive-based Intervention for Enhancing Cognitive Functions and Well-being in Older Adults with Mild Cognitive Impairment: Behavioral and EEG Evidence.Psychosocial intervention · 2025Article
- What factors preventing the older adults in China from living longer: a machine learning study.BMC geriatrics · 2024Article
- Association of time-varying sleep duration and cognitive function with mortality in the elderly: a 12-year community-based cohort study.BMC psychiatry · 2023Article
- Article
- Mild Cognitive Impairment in Rural Areas: Research Advances and Implications for Clinical Practice and Healthcare Policy.Healthcare (Basel, Switzerland) · 2022Review
- Joint developmental trajectories and temporal precedence of physical function decline and cognitive deterioration: A longitudinal population-based study.Frontiers in psychology · 2022Article
- Serum sTREM2: A Potential Biomarker for Mild Cognitive Impairment in Patients With Obstructive Sleep Apnea.Frontiers in aging neuroscience · 2022Article
- Hearing Impairment With Cognitive Decline Increases All-Cause Mortality Risk in Chinese Adults Aged 65 Years or Older: A Population-Based Longitudinal Study.Frontiers in aging neuroscience · 2022Article
- Cognitive impairment and all-cause mortality among Chinese adults aged 80 years or older.Brain and behavior · 2021Article
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Authors and funding
6 authors.
Funding
Abstract
objectivesThe oldest-old (aged ≥80 years) are the fastest growing population segment and age is related to cognitive impairment. We aimed to estimate the association between cognitive impairment and all-cause mortality, in addition to the relationship with different cognitive subdomains among the oldest-old in China.
methodsWe analyzed 25,285 participants recruited from 22 out of 30 provinces in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) from 1998 to 2008, with mortality follow-up until 2014. Cognitive function was measured by the Chinese-version 30-item Mini-Mental State Examination (MMSE), classified as no (MMSE score: 25-30), mild (18-24), moderate (10-17), and severe (0-9) impairment. We used time-dependent Cox model to evaluate the relationship between time-varying cognition and mortality.
resultsThe relationship between cognition and mortality showed a dose-response pattern among the overall population. Compared to those with no impairment, participants with moderate (HR = 1.41, 95% CI 1.28-1.56) and severe (HR = 1.77, 95% CI 1.59-1.96) cognitive impairment showed increased mortality risk. Impairment in the subdomain of orientation was independently associated with increased mortality risk (HR = 1.20, 95% CI 1.05-1.36) among participants without overall cognitive impairment. Urban and rural residents had similar mortality risk.
conclusionsA consistent dose-response pattern existed between cognitive impairment and all-cause mortality. Orientation was associated with mortality in the population without cognitive impairment. Similar mortality regardless of residence areas indicated scarce health care and treatment for cognitive impairment in China from 1998 to 2014.
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