Evidence map›Paper›PMID 34492631›Full record

ReviewDevelopmental cognitive neuroscience2021

Development of white matter microstructure and executive functions during childhood and adolescence: a review of diffusion MRI studies.

Anne-Lise Goddings, David Roalf, Catherine Lebel, Christian K Tamnes

Open access · goldAbstract readReview
In one paragraph

Review in Developmental cognitive neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. White matter reflects the childhood exposome.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Neuropsychological outcome in pediatric brain tumor survivors treated with proton radiation prior to age 4 years.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 4 countries.

Anne-Lise GoddingsUCL Great Ormond Street Institute of Child Health, University College London, UK. Electronic address: anne-lise.goddings@ucl.ac.uk.
David RoalfDepartment of Psychiatry, University of Pennsylvania, USA; Lifespan Brain Institute, Children's Hospital of Philadelphia and the University of Pennsylvania, USA.
Catherine LebelDepartment of Radiology, University of Calgary, Alberta, Canada.
Christian K TamnesPROMENTA Research Center, Department of Psychology, University of Oslo, Norway; NORMENT, Institute of Clinical Medicine, University of Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
Children's Hospital of Philadelphia · USGreat Ormond Street Hospital · GBUniversity of Calgary · CAUniversity of Oslo · NO

Funding

Ultra-high field GluCEST MRI and MRS in youth at risk for psychosisR01MH120174 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ROALF, DAVID R · 2020 to 2024
$3.8M
Olfactory and facial markers of developmental risk for psychosis in 22q11 deletion syndromeR01MH119185 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ROALF, DAVID R · 2019 to 2024
$3.5M
Department of HealthNIMH NIH HHS R01 MH119185NIMH NIH HHS R01 MH120174
6 · The paper itself

Abstract

Diffusion magnetic resonance imaging (dMRI) provides indirect measures of white matter microstructure that can be used to make inferences about structural connectivity within the brain. Over the last decade, a growing literature of cross-sectional and longitudinal studies have documented relationships between dMRI indices and cognitive development. In this review, we provide a brief overview of dMRI methods and how they can be used to study white matter and connectivity and review the extant literature examining the links between dMRI indices and executive functions during development. We explore the links between white matter microstructure and specific executive functions: inhibition, working memory and cognitive shifting, as well as performance on complex executive function tasks. Concordance in findings across studies are highlighted, and potential explanations for discrepancies between results, together with challenges with using dMRI in child and adolescent populations, are discussed. Finally, we explore future directions that are necessary to better understand the links between child and adolescent development of structural connectivity of the brain and executive functions.

Indexed as

Executive FunctionWhite MatterAdolescentBrainChildCross-Sectional StudiesDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingHumansadolescencebrain developmentdiffusion MRIDTIexecutive functionwhite matter

Identifiers

PMID34492631
PMCPMC8424510
OpenAlexW3170550114

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.