Evidence map›Paper›PMID 34492574›Full record

ArticleMedical image analysis2021

AIforCOVID: Predicting the clinical outcomes in patients with COVID-19 applying AI to chest-X-rays. An Italian multicentre study.

Paolo Soda, Natascha Claudia D'Amico, Jacopo Tessadori, Giovanni Valbusa, Valerio Guarrasi, Chandra Bortolotto, Muhammad Usman Akbar, Rosa Sicilia, Ermanno Cordelli, Deborah Fazzini and 18 more

Abstract readMulticenter Study
In one paragraph

Article in Medical image analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  9. Corticosteroid treatment prediction using chest X-ray and clinical data.Computational and structural biotechnology journal · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Paolo SodaUnit of Computer Systems and Bioinformatics, Department of Engineering, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, Rome 00128, Italy. Electronic address: p.soda@unicampus.it.
Natascha Claudia D'AmicoUnit of Computer Systems and Bioinformatics, Department of Engineering, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, Rome 00128, Italy; Department of Diagnostic Imaging and Stereotactic Radiosurgey, Centro Diagnostico Italiano S.p.A., Via S. Saint Bon 20, Milan 20147, Italy.
Jacopo TessadoriPattern Analysis and Computer Vision, Istituto Italiano di Tecnologia, Via Morego 30, Genoa 16163, Italy.
Giovanni ValbusaBracco Imaging S.p.A., Via Caduti di Marcinelle 13, Milan 20134, Italy.
Valerio GuarrasiUnit of Computer Systems and Bioinformatics, Department of Engineering, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, Rome 00128, Italy; Department of Computer, Control, and Management Engineering, Sapienza University of Rome, Via Ariosto, 25, Rome 00185, Italy.
Chandra BortolottoRadiology Institute, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, Pavia 27100, Italy.
Muhammad Usman AkbarPattern Analysis and Computer Vision, Istituto Italiano di Tecnologia, Via Morego 30, Genoa 16163, Italy; Department of Naval, Electrical, Electronic and Telecommunications Engineering University of Genova, Via All'Opera Pia 11 A, Genoa 16145, Italy.
Rosa SiciliaUnit of Computer Systems and Bioinformatics, Department of Engineering, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, Rome 00128, Italy.
Ermanno CordelliUnit of Computer Systems and Bioinformatics, Department of Engineering, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, Rome 00128, Italy.
Deborah FazziniDepartment of Diagnostic Imaging and Stereotactic Radiosurgey, Centro Diagnostico Italiano S.p.A., Via S. Saint Bon 20, Milan 20147, Italy.
Michaela CellinaRadiology Department, ASST Fatebenefratelli Sacco, Piazza Principessa Clotilde 3, Milan 20121, Italy.
Giancarlo OlivaRadiology Department, ASST Fatebenefratelli Sacco, Piazza Principessa Clotilde 3, Milan 20121, Italy.
Giovanni CalleaRadiology Institute, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, Pavia 27100, Italy.
Silvia PanellaDiagnostic and interventional radiology unit, ASST Santi Paolo e Carlo - San Paolo Hospital, Via Antonio di Rudiní 8, Milan 20142, Italy.
Maurizio CariatiDepartment of Advanced Diagnostic Technologies - Therapeutic, Diagnostic and Radiology Units, ASST Santi Paolo e Carlo - San Paolo Hospital, Via Antonio di Rudiní 8, Milan 20142, Italy.
Diletta CozziDepartment of Emergency Radiology, Careggi University Hospital, Largo Piero Palagi 1, Florence 50139, Italy.
Vittorio MieleDepartment of Emergency Radiology, Careggi University Hospital, Largo Piero Palagi 1, Florence 50139, Italy.
Elvira StellatoPostgraduation School in Radiodiagnostics, Universitá degli Studi di Milano, Via Festa del Perdono, 7, Milan 20122, Italy.
Gianpaolo CarrafielloOperative Unit of Radiology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico of Milan, Via della Commenda, 10, Milan 20122, Italy; Department of Health Sciences, Univeristy of Milan, Via Festa del Perdono, 7, Milan 20122, Italy.
Giulia CastoraniDiagnostic Imaging, Postgraduate Medical School, University of Foggia, Via Antonio Gramsci 89, Foggia 71122, Italy.
Annalisa SimeoneDepartment of Diagnostic Imaging, IRCCS Ospedale Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo 71013, Italy.
Lorenzo PredaRadiology Institute, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, Pavia 27100, Italy; Radiology Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Corso Str. Nuova, 65, Pavia 27100 Italy.
Giulio IannelloUnit of Computer Systems and Bioinformatics, Department of Engineering, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, Rome 00128, Italy.
Alessio Del BuePattern Analysis and Computer Vision, Istituto Italiano di Tecnologia, Via Morego 30, Genoa 16163, Italy.
Fabio TedoldiBracco Imaging S.p.A., Via Caduti di Marcinelle 13, Milan 20134, Italy.
Marco AlíDepartment of Diagnostic Imaging and Stereotactic Radiosurgey, Centro Diagnostico Italiano S.p.A., Via S. Saint Bon 20, Milan 20147, Italy; Bracco Imaging S.p.A., Via Caduti di Marcinelle 13, Milan 20134, Italy.
Diego SonaPattern Analysis and Computer Vision, Istituto Italiano di Tecnologia, Via Morego 30, Genoa 16163, Italy; Fondazione Bruno Kessler, Via Sommarive, 18, Trento 38123, Italy.
Sergio PapaDepartment of Diagnostic Imaging and Stereotactic Radiosurgey, Centro Diagnostico Italiano S.p.A., Via S. Saint Bon 20, Milan 20147, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent epidemiological data report that worldwide more than 53 million people have been infected by SARS-CoV-2, resulting in 1.3 million deaths. The disease has been spreading very rapidly and few months after the identification of the first infected, shortage of hospital resources quickly became a problem. In this work we investigate whether artificial intelligence working with chest X-ray (CXR) scans and clinical data can be used as a possible tool for the early identification of patients at risk of severe outcome, like intensive care or death. Indeed, further to induce lower radiation dose than computed tomography (CT), CXR is a simpler and faster radiological technique, being also more widespread. In this respect, we present three approaches that use features extracted from CXR images, either handcrafted or automatically learnt by convolutional neuronal networks, which are then integrated with the clinical data. As a further contribution, this work introduces a repository that collects data from 820 patients enrolled in six Italian hospitals in spring 2020 during the first COVID-19 emergency. The dataset includes CXR images, several clinical attributes and clinical outcomes. Exhaustive evaluation shows promising performance both in 10-fold and leave-one-centre-out cross-validation, suggesting that clinical data and images have the potential to provide useful information for the management of patients and hospital resources.

Indexed as

COVID-19Artificial IntelligenceHumansItalySARS-CoV-2X-RaysArtificial intelligenceCOVID-19Deep learningPrognosis

Identifiers

PMID34492574
PMCPMC8401374

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.