ReviewInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021
Arthralgia resolution rate following chikungunya virus infection.
Review in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Assessing chikungunya's economic burden and impact on health-related quality of life: Two systematic literature reviews.PLoS neglected tropical diseases · 2025Pooled it
- Expert Recommendations to Strengthen Chikungunya Outbreak Surveillance and Reporting for Traveler Health Protection.The American journal of tropical medicine and hygiene · 2026Article
- Pathogenesis of Chronic Arthritis Due to Chikungunya Virus and Advances in Vaccine Development.Viruses · 2026Review
- Chronic phase of Chikungunya: understanding the impact of joint pain using data science and artificial intelligence.Tropical medicine and health · 2026Article
- A High-Throughput Antiviral Assay Based on a Sindbis Virus-GFP for the Discovery of Inhibitors of Alphavirus Replication.Viruses · 2026Article
- Predicting the global risk of chikungunya virus under climate change using ensemble species distribution models.Frontiers in cellular and infection microbiology · 2026Article
- Predictors of chronic arthralgia following chikungunya virus infection.GMS hygiene and infection control · 2026Article
- Global, regional and national burden of chikungunya: force of infection mapping and spatial modelling study.BMJ global health · 2025Article
- Cost-effectiveness of chikungunya vaccination with the live attenuated vaccine in U.S. territories.NPJ vaccines · 2025Article
- Global burden of chikungunya virus infections and the potential benefit of vaccination campaigns.Nature medicine · 2025Article
- Chikungunya virus burden and implications for vaccination programs.Nature medicine · 2025Article
- Modeling the impact of vaccine campaigns on the epidemic transmission dynamics of chikungunya virus outbreaks.Nature medicine · 2025Article
- IL-17 as a putative hallmark of intense arthralgia and age-related serum immune mediator networks during acute chikungunya fever.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Knowledge, attitudes and practice questionnaires in dengue, Zika, chikungunya and yellow fever settings: a scoping review protocol.BMJ open · 2024Article
- The global health and economic burden of chikungunya from 2011 to 2020: a model-driven analysis on the impact of an emerging vector-borne disease.BMJ global health · 2024Article
- Results of a Nationally Representative Seroprevalence Survey of Chikungunya Virus in Bangladesh.The Journal of infectious diseases · 2024Article
- The Natural History of Post-Chikungunya Viral Arthritis Disease Activity and T-cell Immunology: A Cohort Study.Journal of cellular immunology · 2024Article
- Seroepidemiological Reconstruction of Long-term Chikungunya Virus Circulation in Burkina Faso and Gabon.The Journal of infectious diseases · 2023Article
- The clinical manifestation and the influence of age and comorbidities on long-term chikungunya disease and health-related quality of life: a 60-month prospective cohort study in Curaçao.BMC infectious diseases · 2022Article
- Determinants of Health-Related Quality of Life in Chronic Chikungunya Disease in Guadeloupe.Pathogens (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundArthralgia, persistent pain or stiffness of the joints, is the hallmark symptom of chronic chikungunya virus (CHIKV) disease. Associated with significant disability and reduced quality of life, arthralgia can persist for many months following CHIKV infection. Understanding the expected duration of arthralgia persistence is important for managing clinical expectations at the individual-level as well as for estimating long-term burdens on population health following a CHIKV epidemic.
methodsA review of cohort studies reporting the prevalence of arthralgia post-CHIKV infection over multiple time points was conducted. Generalized linear models were used to estimate the average rate of arthralgia resolution following CHIKV infection.
resultsSixteen cohort studies matching the inclusion criteria were identified and included in the analysis. An average rate of arthralgia resolution of 10.85% (95% confidence interval (CI) 9.05-12.66%) per month was estimated across studies, corresponding to an expected median time to arthralgia resolution of 6.39 months (95% CI 5.48-7.66 months) and an expected arthralgia prevalence of 72.21% (95% CI 68.40-76.23%) at 3 months post-CHIKV infection.
conclusionsEstimates of the average rate of arthralgia resolution and the expected prevalence of arthralgia over time post-CHIKV infection were derived. These can help inform expectations regarding the long-term public health burdens associated with CHIKV epidemics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.