Evidence map›Paper›PMID 34492338›Full record

ArticleGenomics, proteomics & bioinformatics2021

GAPIT Version 3: Boosting Power and Accuracy for Genomic Association and Prediction.

Jiabo Wang, Zhiwu Zhang

Abstract read
In one paragraph

Article in Genomics, proteomics & bioinformatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 629 papers.

0numbers the graph read from it
0cells of the map it votes in
629citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

629 citing papers in PubMed.

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  6. Genome-wide characterisation of leaf rust resistance loci in an Eastern European barley collection.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
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  8. A multi-omic dissection of spatial hierarchy-dependent grain development in barley (Hordeum vulgare L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
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  9. Genome-wide association mapping of tan spot resistance in a modified NAM population derived from synthetic hexaploid wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
    Article
  10. Evaluating reaction norm and fixed effect models for genomic selection of end-use quality in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
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  15. Identification of septoria nodorum blotch susceptibility genes in hard winter wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
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  18. Multi-variant GWAS and genomic prediction dissect the genetic architecture underlying tomato fruit weight.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
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  20. Article

569 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jiabo WangKey Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Sichuan Province and Ministry of Education, Southwest Minzu University, Chengdu 610041, China; Department of Crop and Soil Sciences, Washington State University, Pullman, WA 99164, USA. Electronic address: 23900011@swun.edu.cn.
Zhiwu ZhangDepartment of Crop and Soil Sciences, Washington State University, Pullman, WA 99164, USA. Electronic address: zhiwu.zhang@wsu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome-wide association study (GWAS) and genomic prediction/selection (GP/GS) are the two essential enterprises in genomic research. Due to the great magnitude and complexity of genomic and phenotypic data, analytical methods and their associated software packages are frequently advanced. GAPIT is a widely-used genomic association and prediction integrated tool as an R package. The first version was released to the public in 2012 with the implementation of the general linear model (GLM), mixed linear model (MLM), compressed MLM (CMLM), and genomic best linear unbiased prediction (gBLUP). The second version was released in 2016 with several new implementations, including enriched CMLM (ECMLM) and settlement of MLMs under progressively exclusive relationship (SUPER). All the GWAS methods are based on the single-locus test. For the first time, in the current release of GAPIT, version 3 implemented three multi-locus test methods, including multiple loci mixed model (MLMM), fixed and random model circulating probability unification (FarmCPU), and Bayesian-information and linkage-disequilibrium iteratively nested keyway (BLINK). Additionally, two GP/GS methods were implemented based on CMLM (named compressed BLUP; cBLUP) and SUPER (named SUPER BLUP; sBLUP). These new implementations not only boost statistical power for GWAS and prediction accuracy for GP/GS, but also improve computing speed and increase the capacity to analyze big genomic data. Here, we document the current upgrade of GAPIT by describing the selection of the recently developed methods, their implementations, and potential impact. All documents, including source code, user manual, demo data, and tutorials, are freely available at the GAPIT website (http://zzlab.net/GAPIT).

Indexed as

Genome-Wide Association StudyGenomicsBayes TheoremGenomeGenotypeLinkage DisequilibriumModels, GeneticPhenotypePolymorphism, Single NucleotideGAPITGenomic selectionGWASRSoftware

Identifiers

PMID34492338
PMCPMC9121400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.