Evidence map›Paper›PMID 34492207›Full record

ArticlePhysiological genomics2021

SARS-CoV-2 transgressing LncRNAs uncovers the known unknowns.

Nidhi Shukla, Anchita Prasad, Uma Kanga, Renuka Suravajhala, Vinod Kumar Nigam, P B Kavi Kishor, Rathnagiri Polavarapu, Gyaneshwer Chaubey, Keshav K Singh, Prashanth Suravajhala

Open access · greenAbstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Inferring Recombination Events in SARS-CoV-2 Variants In Silico.Advances in experimental medicine and biology · 2023
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Nidhi ShuklaDepartment of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Jaipur, India.
Anchita PrasadDepartment of Bioengineering, Birla Institute of Technology Mesra, Ranchi, India.
Uma KangaDepartment of Transplant Immunology and Immunogenetics, AIIMS, New Delhi, India.
Renuka SuravajhalaDepartment of Chemistry, Manipal University Jaipur, Jaipur, India.
Vinod Kumar NigamDepartment of Bioengineering, Birla Institute of Technology Mesra, Ranchi, India.
P B Kavi KishorDepartment of Biotechnology, Vignan's Foundation for Science, Technology & Research (VFSTR), Guntur, India.
Rathnagiri PolavarapuDepartment of Biotechnology, Amity University, Jaipur, India.
Gyaneshwer ChaubeyCytogenetics Lab, Department of Zoology, Banaras Hindu University, Varanasi, India.
Keshav K SinghDepartment of Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Prashanth SuravajhalaDepartment of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Jaipur, India.ORCID 0000-0002-8535-278X
Birla Institute of Scientific Research · INBirla Institute of Technology, Mesra · INAll India Institute of Medical Sciences Raipur · INBanaras Hindu University · INManipal University JaipurUniversity of Alabama at Birmingham · USVignan's Foundation for Science, Technology & Research · IN

Funding

NA NA
6 · The paper itself

Abstract

SARS-CoV-2 harbors many known unknown regions in the form of hypothetical open reading frames (ORFs). Although the mechanisms underlying the disease pathogenesis are not clearly understood, molecules such as long noncoding RNAs (lncRNAs) play a key regulatory role in the viral pathogenesis from endocytosis. We asked whether or not the lncRNAs in the host are associated with the viral proteins and argue that lncRNA-mRNAs molecules related to viral infection may regulate SARS-CoV-2 pathogenesis. Toward the end of the perspective, we provide challenges and insights into investigating these transgression pathways.

Indexed as

Angiotensin-Converting Enzyme 2COVID-19EpitopesFemaleGene Expression RegulationHost-Pathogen InteractionsHumansMaleOpen Reading FramesPhylogenyProtein Interaction MapsRNA, Long NoncodingRNA, MessengerSARS-CoV-2Sex FactorsACE2 protein, humanAngiotensin-Converting Enzyme 2EpitopesRNA, Long NoncodingRNA, Messengerfunctional genomicshost pathogenesislncRNAsSARS-CoV-2transgression

Identifiers

PMID34492207
PMCPMC8562947
OpenAlexW3198469536

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.