Evidence map›Paper›PMID 34492072›Full record

ArticlePloS one2021

Association of the functionally significant polymorphisms of the MMP9 gene with H. pylori-positive gastric ulcer in the Caucasian population of Central Russia.

Volodymyr Dvornyk, Irina Ponomarenko, Oksana Minyaylo, Evgeny Reshetnikov, Mikhail Churnosov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Genetic diversity and camphor profiling ofFrontiers in pharmacology · 2026
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  5. Chronic Cadmium Exposure and Genetic Polymorphisms ofInternational journal of environmental research and public health · 2022
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  6. Maternal polymorphic loci of rs1979277International journal of reproductive biomedicine · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Volodymyr DvornykDepartment of Life Sciences, College of Science and General Studies, Alfaisal University, Riyadh, Saudi Arabia.ORCID 0000-0002-2535-103X
Irina PonomarenkoDepartment of Medical Biological Disciplines, Belgorod State University, Belgorod, Russia.
Oksana MinyayloDepartment of Medical Biological Disciplines, Belgorod State University, Belgorod, Russia.
Evgeny ReshetnikovDepartment of Medical Biological Disciplines, Belgorod State University, Belgorod, Russia.ORCID 0000-0002-5429-6666
Mikhail ChurnosovDepartment of Medical Biological Disciplines, Belgorod State University, Belgorod, Russia.
Belgorod National Research University · RUAlfaisal University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe study analyzed the association of functionally significant polymorphisms of matrix metalloproteinases (MMPs) genes with the development of gastric ulcer (GU) in Caucasians from Central Russia.

methodsThe 781 participants, including 434 patients with GU (196 Helicobacter pylori (H. pylori)-positive and 238 H. pylori-negative) and 347 controls (all H. pylori-negative) were recruited for the study. Ten SNPs of the MMP1 (rs1799750), MMP2 (rs243865), MMP3 (rs679620), MMP8 (rs1940475), and MMP9 (rs3918242, rs3918249, rs3787268, rs17576, rs17577, and rs2250889) genes were considered for association with GU using multiple logistic regression. The SNPs associated with GU and loci linked (r2≥0.8) to them were analyzed in silico for their functional assignments.

resultsThe SNPs of the MMP9 gene were associated with H. pylori-positive GU: alleles C of rs3918249 (OR = 2.02, pperm = 0.008) and A of rs3787268 (OR = 1.60-1.82, pperm ≤ 0.016), and eight haplotypes of all studied MMP9 gene SNPs (OR = 1.85-2.04, pperm ≤ 0.016) increased risk for H. pylori-positive GU. None of the analyzed SNPs was independently associated with GU and H. pylori-negative GU. Two haplotypes of the MMP9 gene (contributed by rs3918242, rs3918249, rs17576, and rs3787268) increased risk for GU (OR = 1.62-1.65, pperm ≤ 0.006). Six loci of the MMP9 gene, which are associated with H. pylori-positive GU, and 65 SNPs linked to them manifest significant epigenetic effects, have pronounced eQTL (17 genes) and sQTL (6 genes) values.

conclusionSNPs of the MMP9 were associated with H. pylori-positive GU but not with H. pylori-negative GU in Caucasians of Central Russia.

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseAdultAgedFemaleHelicobacter pyloriHumansLinkage DisequilibriumMaleMatrix Metalloproteinase 9Middle AgedPhenotypePolymorphism, Single NucleotideQuantitative Trait LociRussiaStomach UlcerMatrix Metalloproteinase 9MMP9 protein, human

Identifiers

PMID34492072
PMCPMC8423286
OpenAlexW3196341526

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.