ArticlePLoS computational biology2021
ASCENT (Automated Simulations to Characterize Electrical Nerve Thresholds): A pipeline for sample-specific computational modeling of electrical stimulation of peripheral nerves.
Article in PLoS computational biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 65 citations in OpenAlex.
- Accelerating the development of bioelectronic medicine: outcomes and innovations from the NIH SPARC initiative.Bioelectronic medicine · 2026Review
- Accelerating the development of bioelectronic medicine: overview and impact of the NIH Stimulating Peripheral Activity to Relieve Conditions (SPARC) initiative.Bioelectronic medicine · 2026Review
- Asymmetric tripolar nerve cuff electrode designs for optimizing anodal block of myelinated fibers.Biomedical engineering online · 2026Article
- The optimization of neuroprosthetic interfaces relying on biophysical and surrogate digital twins.npj biomedical innovations · 2026Review
- Computational modeling of human vagus nerve stimulation with three-dimensional fascicular morphology.APL bioengineering · 2026Article
- Identification of low threshold off-target activation pathways during stimulation of carotid baroreceptor afferents in swine.bioRxiv : the preprint server for biology · 2026Article
- PyFibers: An open-source NEURON-Python package to simulate responses of model nerve fibers to electrical stimulation.PLoS computational biology · 2025Article
- The human vagal complex: from gross anatomy to single neurons, from brainstem to abdomen.Research square · 2025Article
- Biophysical characterization of the recording of unmyelinated and myelinated fiber activity with peripheral interfaces.iScience · 2025Article
- Scaling of vagus nerve stimulation parameters does not achieve equivalent nerve responses across species.Bioelectronic medicine · 2025Article
- Control of spatiotemporal activation of organ-specific fibers in the swine vagus nerve by intermittent interferential current stimulation.Nature communications · 2025Article
- Guidance for sharing computational models of neural stimulation: from project planning to publication.Journal of neural engineering · 2025Review
- Recent advances in facilitating the translation of bioelectronic medicine therapies.Current opinion in biomedical engineering · 2025Article
- Characterization of Machine Learning-Based Surrogate Models of Neural Activation Under Electrical Stimulation.Bioelectromagnetics · 2025Article
- Computational modeling of autonomic nerve stimulation: Vagus et al.Current opinion in biomedical engineering · 2024Article
- Laterality, sexual dimorphism, and human vagal projectome heterogeneity shape neuromodulation to vagus nerve stimulation.Communications biology · 2024Article
- Highly efficient modeling and optimization of neural fiber responses to electrical stimulation.Nature communications · 2024Article
- Towards enhanced functionality of vagus neuroprostheses through in silico optimized stimulation.Nature communications · 2024Article
- NRV: An open framework for in silico evaluation of peripheral nerve electrical stimulation strategies.PLoS computational biology · 2024Article
- Recent advances in enhances peripheral nerve orientation: the synergy of micro or nano patterns with therapeutic tactics.Journal of nanobiotechnology · 2024Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Electrical stimulation and block of peripheral nerves hold great promise for treatment of a range of disease and disorders, but promising results from preclinical studies often fail to translate to successful clinical therapies. Differences in neural anatomy across species require different electrodes and stimulation parameters to achieve equivalent nerve responses, and accounting for the consequences of these factors is difficult. We describe the implementation, validation, and application of a standardized, modular, and scalable computational modeling pipeline for biophysical simulations of electrical activation and block of nerve fibers within peripheral nerves. The ASCENT (Automated Simulations to Characterize Electrical Nerve Thresholds) pipeline provides a suite of built-in capabilities for user control over the entire workflow, including libraries for parts to assemble electrodes, electrical properties of biological materials, previously published fiber models, and common stimulation waveforms. We validated the accuracy of ASCENT calculations, verified usability in beta release, and provide several compelling examples of ASCENT-implemented models. ASCENT will enable the reproducibility of simulation data, and it will be used as a component of integrated simulations with other models (e.g., organ system models), to interpret experimental results, and to design experimental and clinical interventions for the advancement of peripheral nerve stimulation therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.