Evidence map›Paper›PMID 34491883›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Transvenous Diaphragm Neurostimulation Mitigates Ventilation-associated Brain Injury.

Thiago G Bassi, Elizabeth C Rohrs, Karl C Fernandez, Marlena Ornowska, Michelle Nicholas, Matt Gani, Doug Evans, Steven C Reynolds

2 registry-linked trialsAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05886647 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Non-invasive Neurostimulation and Rehabilitation in the Treatment of Patients With Respiratory Disorders: Randomized Controlled Clinical Trial

TypeinterventionalSponsorSuellen AndradeRan2023 to 2024Enrolled30ConditionsLung DiseasesArmsActive non-invasive stimulation and inspiratory muscle training, Sham compatorator and inspiratory muscle training
NCT07082569 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Ventilation Mode in the Pupillary Light Reflex: A Crossover Study

TypeinterventionalSponsorEvangelismos HospitalRan2025 to 2026Enrolled36ConditionsMechanical Ventilation, Critical IllnessArmsVolume Control Ventilation, Pressure Control Ventilation, Pressure-Regulated Volume Control (PRVC)
3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Organ crosstalk: brain-lung interaction.Frontiers in medicine · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Ventilator-associated Brain Injury: A New Priority for Research in Mechanical Ventilation.American journal of respiratory and critical care medicine · 2024
    Article
  8. Review
  9. Diaphragm Neurostimulation Assisted Ventilation in Critically Ill Patients.American journal of respiratory and critical care medicine · 2023
    Review
  10. Review
  11. Risk factors for ventilator-induced-lung injury develop three to five times faster after a single episode of lung injury.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Reply to SalimiAmerican journal of respiratory and critical care medicine · 2022
    Article
  18. Stimulating Neural Pathways to Reduce Mechanical Ventilation-associated Neurocognitive Dysfunction.American journal of respiratory and critical care medicine · 2022
    Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Thiago G BassiSimon Fraser University, Burnaby, British Columbia, Canada.ORCID 0000-0001-5570-5057
Elizabeth C RohrsSimon Fraser University, Burnaby, British Columbia, Canada.
Karl C FernandezSimon Fraser University, Burnaby, British Columbia, Canada.
Marlena OrnowskaSimon Fraser University, Burnaby, British Columbia, Canada.
Michelle NicholasSimon Fraser University, Burnaby, British Columbia, Canada.
Matt GaniLungpacer Medical Inc., Vancouver, British Columbia, Canada; and.
Doug EvansLungpacer Medical Inc., Vancouver, British Columbia, Canada; and.
Steven C ReynoldsSimon Fraser University, Burnaby, British Columbia, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ApoptosisAnimalsBrain InjuriesDiaphragmElectric Stimulation TherapyEncephalitisFemaleHippocampusPhrenic NerveRespiration, ArtificialSwineTreatment Outcomeapoptosisbrain injuriesICUmechanical ventilatorspost-ICU syndrome

Identifiers

PMID34491883
PMCPMC8865722

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.