Evidence map›Paper›PMID 34491878›Full record

ReviewHuman vaccines & immunotherapeutics2022

The prospect of orally administered monoclonal secretory IgA (SIgA) antibodies to prevent enteric bacterial infections.

Angelene Richards, Danielle Baranova, Nicholas J Mantis

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Human vaccines & immunotherapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  10. Special focus issue: passive immunization.Human vaccines & immunotherapeutics · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Angelene RichardsDepartment of Biomedical Sciences, University at Albany School, Albany, NY, USA.ORCID 0000-0002-8189-4653
Danielle BaranovaDepartment of Biomedical Sciences, University at Albany School, Albany, NY, USA.ORCID 0000-0003-2318-428X
Nicholas J MantisDepartment of Biomedical Sciences, University at Albany School, Albany, NY, USA.ORCID 0000-0002-5083-8640
University at Albany, State University of New York · USNew York State Department of Health · US

Funding

Mechanisms of IgA-mediated immunity to SalmonellaR03AI119647 · NIAID · WADSWORTH CENTER · PI MANTIS, NICHOLAS J. · 2015 to 2016
$145k
NIAID NIH HHS R03 AI119647
6 · The paper itself

Abstract

Eliminating diarrheal diseases as a leading cause of childhood morbidity and mortality in low- and middle-income countries (LMICs) will require multiple intervention strategies. In this review, we spotlight a series of preclinical studies investigating the potential of orally administered monoclonal secretory IgA (SIgA) antibodies (MAbs) to reduce disease associated with three enteric bacterial pathogens:

Indexed as

Enterotoxigenic Escherichia coliAnimalsAntibodies, BacterialAntibodies, MonoclonalAntigens, BacterialImmunoglobulin AImmunoglobulin A, SecretoryImmunoglobulin GMiceSalmonella typhimuriumAntibodies, BacterialAntibodies, MonoclonalAntigens, BacterialImmunoglobulin AImmunoglobulin A, SecretoryImmunoglobulin GantibodyEntericinfectionprophylactic

Identifiers

PMID34491878
PMCPMC9103515
OpenAlexW3197655129

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.